{"id":"W4381510354","doi":"10.1038/s41398-023-02510-6","title":"Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations","year":2023,"lang":"en","type":"review","venue":"Translational Psychiatry","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Stem Cell Network","keywords":"Induced pluripotent stem cell; Autism spectrum disorder; Neuroscience; Context (archaeology); Organoid; Autism; Neurodevelopmental disorder; Biology; Computational biology; Embryonic stem cell; Psychology; Computer science; Psychiatry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001031519,0.0005758881,0.0007642206,0.001341664,0.0002059825,0.0009618171,0.0009221731,0.001144936,0.002642505],"category_scores_gemma":[0.0008785392,0.0002259446,0.0004338136,0.001232952,0.0005357215,0.001086702,0.000578046,0.002011811,0.001418813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005473131,"about_ca_system_score_gemma":0.0009794879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101237,"about_ca_topic_score_gemma":0.001681889,"domain_scores_codex":[0.9997643,0.00005096011,0.00003356259,0.00004160719,0.00009227112,0.00001727354],"domain_scores_gemma":[0.9994175,0.0003332602,0.00004830406,0.00002783116,0.0001298185,0.00004329708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005846833,0.00005218782,0.0001521105,0.01072403,0.00007324729,0.0002137685,0.00006245873,0.0007023741,0.005307606,0.0170005,0.02591396,0.9397394],"study_design_scores_gemma":[0.000009755305,0.00008685261,0.0003373865,0.001735485,0.00006986594,0.0008738255,0.00003592668,0.0001382257,0.001633091,0.004168482,0.9908955,0.00001569799],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002196725,0.9954373,0.0009249472,0.0006030671,0.000247827,0.00000854134,0.00005361619,0.00001871613,0.002486256],"genre_scores_gemma":[0.001128242,0.9969969,0.0006253214,0.0003161633,0.0001082081,0.00001537523,0.00006839722,0.000003798025,0.0007376661],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002642505,"threshold_uncertainty_score":0.008840084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.152744454487231,"score_gpt":0.3332071352746062,"score_spread":0.1804626807873752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}