{"id":"W4381513704","doi":"10.26434/chemrxiv-2023-52p7p","title":"Open Source Antibiotics - Simple Diarylimidazoles are Potent Against Methicillin Resistant Staphylococcus Aureus","year":2023,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Direktion für Entwicklung und Zusammenarbeit; University of North Carolina at Chapel Hill; Genentech; Agence Française de Développement; National Institute of Allergy and Infectious Diseases; Pharmaron; Ministerio de Educación, Cultura y Deporte; University of Queensland; Monash University; Ontario Genomics Institute; University College London; Wellcome Trust; Bayer; Drugs for Neglected Diseases initiative; Merck KGaA; Ontario Genomics; AstraZeneca; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Bristol-Myers Squibb; McGill University; Boehringer Ingelheim; Pfizer; European Federation of Pharmaceutical Industries and Associations; Takeda Pharmaceutical Company","keywords":"Antimicrobial; Antibiotics; Staphylococcus aureus; Potency; Chemistry; Methicillin-resistant Staphylococcus aureus; Antibiotic resistance; Microbiology; Bacteria; Biology; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003497002,0.0003792227,0.0003443402,0.000387166,0.0002171182,0.0005095821,0.0004967485,0.0004499371,0.01571512],"category_scores_gemma":[0.000535635,0.0001927203,0.0002997829,0.0004791864,0.0002070902,0.0004194088,0.0006295381,0.0004548437,0.007189007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549615,"about_ca_system_score_gemma":0.0005325942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004599554,"about_ca_topic_score_gemma":0.0007303777,"domain_scores_codex":[0.9997163,0.00002994801,0.00001517691,0.00004100057,0.0001637493,0.00003376303],"domain_scores_gemma":[0.9998081,0.00004413571,0.00003601399,0.00003774666,0.00004529547,0.00002876938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001209459,0.0004366263,0.001085751,0.001350069,0.00006470364,0.0007039694,0.0001236973,0.001978401,0.7780152,0.005483931,0.03114158,0.1784066],"study_design_scores_gemma":[0.0002347519,0.000647267,0.003499304,0.00008391501,0.00004279237,0.0008654491,0.00004839277,0.003793854,0.7175614,0.002162759,0.2710251,0.00003510748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.630784,0.02617089,0.1166943,0.003487635,0.001184185,0.0006314436,0.04984866,0.02531533,0.1458836],"genre_scores_gemma":[0.7210202,0.01717129,0.0791945,0.0006372699,0.0002482155,0.0004685887,0.05809801,0.002874594,0.1202873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01571512,"threshold_uncertainty_score":0.05257231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04983972800408931,"score_gpt":0.3042916556099235,"score_spread":0.2544519276058342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}