{"id":"W4381549542","doi":"10.1016/j.sbi.2023.102644","title":"The conformationally dynamic structural biology of lanthipeptide biosynthesis","year":2023,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Thioether; Intramolecular force; Computational biology; Synthetic biology; Peptide; Biosynthesis; Enzyme; Structural biology; Biology; Biochemistry; Chemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006057327,0.0008038633,0.001093403,0.0007657624,0.000179995,0.001302956,0.0008795836,0.001115277,0.002241442],"category_scores_gemma":[0.0004383528,0.0002677234,0.0002878689,0.001188415,0.000885734,0.001792958,0.0008465677,0.001967143,0.001511167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008787036,"about_ca_system_score_gemma":0.0009551352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005631128,"about_ca_topic_score_gemma":0.0008776552,"domain_scores_codex":[0.9998686,0.00002163363,0.00001181105,0.0000267649,0.0000468418,0.0000243288],"domain_scores_gemma":[0.9998375,0.00006518586,0.00002931753,0.000006406942,0.00003564615,0.00002595064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001644378,0.0000567442,0.0001263201,0.01121224,0.00005324746,0.0002618626,0.00005603109,0.0009851251,0.01345099,0.01506452,0.02909467,0.9294737],"study_design_scores_gemma":[0.00002694706,0.00009193242,0.0003598071,0.001140456,0.00005060666,0.0007438126,0.00004293285,0.0003115371,0.002223801,0.006059254,0.9889274,0.0000216069],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002368936,0.9971078,0.0003685884,0.0007113255,0.0003503227,0.000003658098,0.00001669544,0.00001071795,0.001193962],"genre_scores_gemma":[0.001227511,0.9972934,0.000192005,0.000305342,0.0003492584,0.000004151645,0.00003359545,0.000001390136,0.0005933353],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002241442,"threshold_uncertainty_score":0.007498324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08025703585585081,"score_gpt":0.4100159423033407,"score_spread":0.3297589064474899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}