{"id":"W4381549775","doi":"10.1016/j.celrep.2023.112668","title":"FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"H2020 European Research Council; European Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"RAD51; Dynamics (music); Biology; Computational biology; Cell biology; Genetics; DNA repair; Gene; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002844195,0.001246746,0.0004906569,0.0007311458,0.0003567777,0.0003720461,0.000541044,0.001195085,0.005566437],"category_scores_gemma":[0.0003636307,0.0002873769,0.0006192981,0.0003609969,0.0006010451,0.0001456648,0.0004593041,0.0008520189,0.001412574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003968749,"about_ca_system_score_gemma":0.0002393035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008556487,"about_ca_topic_score_gemma":0.001189385,"domain_scores_codex":[0.9995919,0.00006787716,0.00005173593,0.0001296273,0.00009886699,0.00006001598],"domain_scores_gemma":[0.9994399,0.0001186301,0.0002428786,0.00007453743,0.00001707086,0.0001070023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002371845,0.00007087482,0.0008604162,0.00006995811,0.00003203276,0.002325828,0.00001926108,0.000254124,0.9931616,0.0003103489,0.0003411898,0.002317217],"study_design_scores_gemma":[0.0001955336,0.0007704669,0.04087734,0.00006418541,0.00009912677,0.02020889,0.00008928469,0.005278024,0.9197382,0.0003038954,0.01231112,0.00006408705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839854,0.0008564651,0.007205353,0.0002890003,0.0001598816,0.00008922196,0.003239986,0.0007773081,0.003397393],"genre_scores_gemma":[0.9902131,0.0002276164,0.002890274,0.0001469512,0.00003316276,0.00006023256,0.002604098,0.0001491557,0.003675424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005566437,"threshold_uncertainty_score":0.01862162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004814970270666801,"score_gpt":0.2060598869334899,"score_spread":0.2012449166628231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}