{"id":"W4381549775","doi":"10.1016/j.celrep.2023.112668","title":"FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"H2020 European Research Council; European Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"RAD51; Dynamics (music); Biology; Computational biology; Cell biology; Genetics; DNA repair; Gene; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000202759,0.0001523167,0.0001371561,0.00004058536,0.00005757028,0.00002424366,0.0000705885,0.0001341438,0.0000255654],"category_scores_gemma":[0.00005006147,0.0001313911,0.00004465287,0.0001042471,0.00007041958,0.000002857005,0.0001250363,0.00006830855,0.00001394803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001133429,"about_ca_system_score_gemma":0.00006036645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001615138,"about_ca_topic_score_gemma":0.00002214004,"domain_scores_codex":[0.9989154,0.00002067742,0.0001855709,0.0004647056,0.000162696,0.0002509056],"domain_scores_gemma":[0.9992558,0.00001422774,0.0001083369,0.0004740567,0.00004433055,0.0001032796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005925904,0.00009420365,0.02272438,0.0001792075,0.0001086516,0.002848989,0.0002896895,0.00005616616,0.9627614,0.00009192485,0.006742474,0.004043679],"study_design_scores_gemma":[0.0002444963,0.0002720664,0.00155635,0.00002421362,0.00004629388,0.0009423225,0.0001700278,0.0007093067,0.9825246,0.0005211458,0.01266274,0.0003264183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995392,0.000318261,0.0001649415,0.0001297423,0.0002121056,0.0001510392,0.000007410432,0.00006242398,0.00356213],"genre_scores_gemma":[0.9925975,0.000144958,0.0004639046,0.00009195799,0.00007107732,0.00002177986,0.0001267402,0.00003872585,0.006443316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02116803,"threshold_uncertainty_score":0.5357974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004814970270666801,"score_gpt":0.2060598869334899,"score_spread":0.2012449166628231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}