{"id":"W4381570667","doi":"10.3390/genes14061194","title":"Peptides of a Feather: How Computation Is Taking Peptide Therapeutics under Its Wing","year":2023,"lang":"en","type":"review","venue":"Genes","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke; Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Wing; Feather; Peptide; Biology; Computational biology; Zoology; Biochemistry; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001277338,0.0002646101,0.0007111265,0.00006652565,0.00005214549,0.00003722402,0.0002058046,0.0002682309,0.00001323895],"category_scores_gemma":[0.000029943,0.0002133309,0.0006487516,0.0002010881,0.00003837265,0.000002003347,0.0001133218,0.00007718304,0.00001504649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001663429,"about_ca_system_score_gemma":0.00006434484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007271432,"about_ca_topic_score_gemma":0.000007900418,"domain_scores_codex":[0.9989184,0.00006622214,0.0003045577,0.0003690769,0.0001531046,0.0001885949],"domain_scores_gemma":[0.9991727,0.00005329349,0.0004207079,0.0002383565,0.00007769965,0.00003719836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002499692,0.00002720808,0.00001846207,0.003684678,0.001134362,0.000001298356,0.00003197294,0.00002626692,0.04492665,0.000008814242,0.0003561057,0.9497817],"study_design_scores_gemma":[0.00009201956,0.0000380097,0.00001219512,0.002594696,0.001408833,0.000007641239,0.0001097327,0.00007062437,0.02877136,0.00004454703,0.9663892,0.0004611253],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002360063,0.996792,0.0004558802,0.00005536601,0.00004503597,0.0001387248,0.00005110043,0.00001550753,0.00008639287],"genre_scores_gemma":[0.00329335,0.9948396,0.0002714636,0.00005941939,0.0002801401,0.00001854583,0.0002052471,0.00006305606,0.0009691576],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9660331,"threshold_uncertainty_score":0.869938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1251303897266544,"score_gpt":0.3615960715037027,"score_spread":0.2364656817770483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}