{"id":"W4381597738","doi":"10.1084/jem.20230661","title":"Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients","year":2023,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institutes of Health; Ministero della Difesa; Fondation Bettencourt Schueller; Ministero della Salute; Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; European Society for Immunodeficiencies; Hospital for Sick Children; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; Università degli Studi di Pavia; Assistance Publique - Hôpitaux de Paris; European Commission; SCOR Corporate Foundation for Science; Institut des maladies génétiques Imagine; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Assistance publique-Hôpitaux de Paris; Meyer Foundation; Rockefeller University; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; Horizon 2020 Framework Programme; Open Square Foundation; Fondation pour la Recherche Médicale; JPB Foundation; Georgia Clinical and Translational Science Alliance; Howard Hughes Medical Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Fondazione IRCCS Policlinico San Matteo; Università degli Studi di Padova; St. Giles Foundation","keywords":"Encephalitis; Virology; Neutralizing antibody; Japanese encephalitis; Antibody; Population; Vero cell; Medicine; Flavivirus; Autoantibody; Immunology; Titer; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002757225,0.0002907809,0.0002979102,0.0003351478,0.0004718332,0.0004770724,0.0001665676,0.0003622672,0.003212131],"category_scores_gemma":[0.00122379,0.0002288082,0.0002559398,0.0003080501,0.0002654137,0.0003483734,0.0002819905,0.0004959475,0.000324767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001970608,"about_ca_system_score_gemma":0.000224606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001779206,"about_ca_topic_score_gemma":0.001830197,"domain_scores_codex":[0.9997008,0.00005679367,0.00003118789,0.00006959435,0.00005999173,0.00008172557],"domain_scores_gemma":[0.9995604,0.00008719101,0.000190756,0.00003257363,0.00004320897,0.00008572764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001881918,0.00004025937,0.9898769,0.00001610655,0.00004886166,0.0009853801,0.0001206153,0.00004021302,0.001160648,0.00008275022,0.0005132967,0.006926751],"study_design_scores_gemma":[0.00001798128,0.0001743554,0.9870719,0.00002625496,0.00006933342,0.01042655,0.0003214269,0.0001795983,0.0004082293,0.0001432865,0.001153681,0.000007365602],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964572,0.001043426,0.0001364193,0.000119868,0.00002100284,0.00000916516,0.0001426605,0.00001457947,0.002055728],"genre_scores_gemma":[0.9994515,0.0001741666,0.00003005508,0.00007760142,0.00001951269,0.000002812963,0.00008001506,0.000001232996,0.0001631562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003212131,"threshold_uncertainty_score":0.01074564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03164836357683528,"score_gpt":0.3366050980612608,"score_spread":0.3049567344844255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}