{"id":"W4381597738","doi":"10.1084/jem.20230661","title":"Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients","year":2023,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institutes of Health; Ministero della Difesa; Fondation Bettencourt Schueller; Ministero della Salute; Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; European Society for Immunodeficiencies; Hospital for Sick Children; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; Università degli Studi di Pavia; Assistance Publique - Hôpitaux de Paris; European Commission; SCOR Corporate Foundation for Science; Institut des maladies génétiques Imagine; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Assistance publique-Hôpitaux de Paris; Meyer Foundation; Rockefeller University; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; Horizon 2020 Framework Programme; Open Square Foundation; Fondation pour la Recherche Médicale; JPB Foundation; Georgia Clinical and Translational Science Alliance; Howard Hughes Medical Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Fondazione IRCCS Policlinico San Matteo; Università degli Studi di Padova; St. Giles Foundation","keywords":"Encephalitis; Virology; Neutralizing antibody; Japanese encephalitis; Antibody; Population; Vero cell; Medicine; Flavivirus; Autoantibody; Immunology; Titer; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004145222,0.0001377156,0.0004727069,0.0001985232,0.00004643976,0.000003958868,0.000172452,0.00003971268,0.0005545338],"category_scores_gemma":[0.0001384875,0.00008106211,0.00008998423,0.0003694005,0.0001885287,0.0000827144,0.00004508961,0.000181554,0.00001471086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000701486,"about_ca_system_score_gemma":0.00007507265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003502509,"about_ca_topic_score_gemma":0.00001698941,"domain_scores_codex":[0.9984708,0.00008868218,0.000623147,0.00009372432,0.0004942556,0.0002294197],"domain_scores_gemma":[0.9990981,0.0001478138,0.0002928509,0.0001859689,0.0001369979,0.0001382439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007983317,0.001878573,0.1409198,0.000248253,0.0004874705,0.0004993333,0.01888471,0.0001084449,0.8082808,0.0009630629,0.01423337,0.005512782],"study_design_scores_gemma":[0.01432076,0.008328054,0.8785443,0.002082103,0.0005191868,0.0001249157,0.03186369,0.000358363,0.06127889,0.0002356791,0.002102914,0.0002411831],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902306,0.006701651,0.000004881202,0.001350079,0.0005608489,0.0002141193,0.000008015531,0.00001329884,0.0009165474],"genre_scores_gemma":[0.998154,0.0008729153,0.00001507473,0.0005138832,0.0002722756,0.000002740712,0.0000135144,0.00001764976,0.0001379392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7470019,"threshold_uncertainty_score":0.6071756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03164836357683528,"score_gpt":0.3366050980612608,"score_spread":0.3049567344844255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}