{"id":"W4381598504","doi":"10.1038/s41598-023-35870-6","title":"A universal tool for stability predictions of biotherapeutics, vaccines and in vitro diagnostic products","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Sanofi","keywords":"Computer science; Computational biology; Data science; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002948424,0.001645484,0.0008393971,0.001826366,0.0004088902,0.001632073,0.0009798351,0.001156829,0.002073787],"category_scores_gemma":[0.004672983,0.0005527544,0.001348935,0.0009687393,0.0003841256,0.001581596,0.001069308,0.001402874,0.001834748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008179503,"about_ca_system_score_gemma":0.0009605999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001547507,"about_ca_topic_score_gemma":0.0008259621,"domain_scores_codex":[0.9986464,0.000328289,0.0001240716,0.0003003146,0.000537281,0.0000636728],"domain_scores_gemma":[0.9981387,0.0006021357,0.0004146101,0.0003910043,0.0004153571,0.00003828579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000440602,0.0002853405,0.01122476,0.0009232376,0.000270155,0.0003426958,0.0004407403,0.545846,0.2352891,0.02012031,0.003687557,0.1811295],"study_design_scores_gemma":[0.00001315343,0.0002154853,0.002251082,0.00009160938,0.00008241931,0.0001739077,0.00005319255,0.889441,0.09222688,0.00612051,0.009265893,0.00006491767],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.03704068,0.0008163498,0.9549155,0.000125678,0.00005481254,0.00007500651,0.0008459698,0.003597772,0.002528118],"genre_scores_gemma":[0.6848865,0.001620024,0.3066727,0.0001202812,0.00004815722,0.0003666587,0.002114444,0.0006877463,0.003483474],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002948424,"threshold_uncertainty_score":0.01559293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01690746982433164,"score_gpt":0.258759618381538,"score_spread":0.2418521485572064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}