{"id":"W4381598508","doi":"10.1021/acs.biomac.3c00210","title":"Bioinspired Oligo-Urethane Nanoparticles for Delivering Exogenous C-Type Natriuretic Peptide: Synthetic Biomaterial Nanocarrier Complexes and Their Interactions with Cardiac Myofibroblasts","year":2023,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Myofibroblast; Cardiac fibrosis; Chemistry; Extracellular matrix; Cell biology; Biophysics; Fibrosis; Transforming growth factor; Biochemistry; Internal medicine; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005482,0.0002881031,0.0001426221,0.0001078157,0.00009219474,0.0001414741,0.0001364372,0.0002695894,0.0003993037],"category_scores_gemma":[0.0001676003,0.0001123014,0.0001552795,0.00007851625,0.0001355808,0.0001480983,0.0001301662,0.0001846794,0.0001667583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001952824,"about_ca_system_score_gemma":0.000136667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004998139,"about_ca_topic_score_gemma":0.000767023,"domain_scores_codex":[0.9998914,0.00001758082,0.000009872864,0.0000301965,0.00003446254,0.00001644744],"domain_scores_gemma":[0.9999089,0.00002225426,0.00002799999,0.00000595554,0.0000172611,0.00001758843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001796367,0.000007630345,0.00003576767,0.00002783382,0.000001794931,0.00001791431,0.00001042364,0.00007242591,0.9990746,0.00002591658,0.00001036397,0.000697331],"study_design_scores_gemma":[0.000005095853,0.000148777,0.0006070542,0.00000282526,0.000006391936,0.00007035621,0.000008527976,0.001015704,0.9973531,0.00001063522,0.0007671739,0.000004369147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922554,0.001331449,0.005242452,0.00004661445,0.00002432739,0.00003979081,0.0000731939,0.00005056358,0.0009361611],"genre_scores_gemma":[0.9887155,0.0008159632,0.008680989,0.00004926659,0.000009991147,0.00007208123,0.00008637778,0.00001784467,0.001552087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004998139,"threshold_uncertainty_score":0.001416862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931556938716433,"score_gpt":0.2587542333396143,"score_spread":0.2394386639524499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}