{"id":"W4381598508","doi":"10.1021/acs.biomac.3c00210","title":"Bioinspired Oligo-Urethane Nanoparticles for Delivering Exogenous C-Type Natriuretic Peptide: Synthetic Biomaterial Nanocarrier Complexes and Their Interactions with Cardiac Myofibroblasts","year":2023,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Myofibroblast; Cardiac fibrosis; Chemistry; Extracellular matrix; Cell biology; Biophysics; Fibrosis; Transforming growth factor; Biochemistry; Internal medicine; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001286018,0.0003043225,0.0004566101,0.0002484504,0.0002059688,0.00004380248,0.00007318804,0.00007781783,0.00001411525],"category_scores_gemma":[0.00008273311,0.0002074673,0.00008902814,0.0004657107,0.0002632542,0.00004806022,0.00005163018,0.00006544335,0.00001878861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004406006,"about_ca_system_score_gemma":0.00005912858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005526211,"about_ca_topic_score_gemma":0.00001728999,"domain_scores_codex":[0.9987366,0.00004479099,0.0002496973,0.0003905584,0.0001576385,0.00042075],"domain_scores_gemma":[0.9992261,0.0001124151,0.00006209753,0.000253772,0.0001350812,0.0002105244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003097971,0.00003605552,0.0002675271,0.0002417093,0.0002532577,0.00007260296,0.0008552825,0.00002631758,0.9958113,0.0001197241,0.0002433195,0.001763115],"study_design_scores_gemma":[0.001415515,0.001260409,0.004011494,0.000489619,0.0001866197,0.0004389743,0.0005595157,0.0008744098,0.9837486,0.0000159744,0.006693698,0.0003052003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938322,0.003306976,0.0006079076,0.0004459565,0.0006816795,0.0006055657,0.000117508,0.0003811662,0.00002107083],"genre_scores_gemma":[0.9972081,0.00009960157,0.001715462,0.00001879026,0.0002942282,0.00007531131,0.0001313164,0.00007602834,0.0003811679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01206272,"threshold_uncertainty_score":0.8460271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931556938716433,"score_gpt":0.2587542333396143,"score_spread":0.2394386639524499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}