{"id":"W4381612561","doi":"10.1038/s41564-023-01409-8","title":"Cut site preference allows influenza A virus PA-X to discriminate between host and viral mRNAs","year":2023,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; School of Medicine, Emory University; Office of Science; Dalhousie University; U.S. Department of Energy; Advanced Scientific Computing Research; Office of Extramural Research, National Institutes of Health; Emory University; University of Pennsylvania; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biology; Viral replication; Influenza A virus; Virus; Endoribonuclease; RNA; Transcriptome; Gene; Viral entry; Virology; Viral pathogenesis; Gene expression; Genetics; Cell biology; RNase P","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003562208,0.0003115369,0.0006198547,0.0004157023,0.0001834718,0.00002790451,0.0002231036,0.0006017014,0.00004389004],"category_scores_gemma":[0.000674863,0.0002383816,0.00008814166,0.0005074012,0.0003035273,0.00007528004,0.0006985978,0.001252048,0.0008651754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009546081,"about_ca_system_score_gemma":0.00008548865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001405121,"about_ca_topic_score_gemma":0.000232129,"domain_scores_codex":[0.9979658,0.0001269024,0.0003187521,0.0006268497,0.0001388641,0.0008228386],"domain_scores_gemma":[0.9988502,0.000254161,0.00006490526,0.0003932327,0.0002007996,0.0002367038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004538244,0.00003079468,0.07016729,0.0001293156,0.0002267285,0.00009744202,0.001396047,0.000001071822,0.9075346,0.0001519745,0.01735573,0.002455203],"study_design_scores_gemma":[0.002141302,0.0009094876,0.448459,0.0001673355,0.0001432001,0.00006741344,0.000162027,0.000005950757,0.0674809,0.000140901,0.4798818,0.0004407022],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930928,0.001861679,0.000006256913,0.002566948,0.0001748367,0.0007546067,0.0005627059,0.000193905,0.0007862903],"genre_scores_gemma":[0.9899589,0.0003386508,0.0004105308,0.007103319,0.0003144358,0.00007094561,0.0002156221,0.00004343015,0.001544157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8400537,"threshold_uncertainty_score":0.9999127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07308241362478145,"score_gpt":0.3783289479065976,"score_spread":0.3052465342818161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}