{"id":"W4381612561","doi":"10.1038/s41564-023-01409-8","title":"Cut site preference allows influenza A virus PA-X to discriminate between host and viral mRNAs","year":2023,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; School of Medicine, Emory University; Office of Science; Dalhousie University; U.S. Department of Energy; Advanced Scientific Computing Research; Office of Extramural Research, National Institutes of Health; Emory University; University of Pennsylvania; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biology; Viral replication; Influenza A virus; Virus; Endoribonuclease; RNA; Transcriptome; Gene; Viral entry; Virology; Viral pathogenesis; Gene expression; Genetics; Cell biology; RNase P","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004256995,0.0003616516,0.0004006447,0.0001903427,0.0003232272,0.001005776,0.0003765988,0.0006307897,0.004421771],"category_scores_gemma":[0.0005397996,0.0004743894,0.0004405082,0.0001128555,0.0005241458,0.0005177877,0.0005600236,0.001655712,0.001858959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002757233,"about_ca_system_score_gemma":0.0002529098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003267163,"about_ca_topic_score_gemma":0.0004342915,"domain_scores_codex":[0.9996368,0.00007029418,0.00002359888,0.0001141742,0.0000683663,0.00008677244],"domain_scores_gemma":[0.9991935,0.0003688132,0.0001041498,0.0001078275,0.00006512498,0.0001606252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002235267,0.00002334454,0.0002937872,0.00001072881,0.000003914028,0.00003139929,0.000009307441,0.00004031976,0.9981455,0.0002141116,0.00003778238,0.0009662401],"study_design_scores_gemma":[0.00001554077,0.0002421931,0.002460585,0.000003141765,0.000006665347,0.0003259087,0.00003349596,0.001029291,0.9949385,0.0001455517,0.0007899553,0.000009119924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912544,0.0004126257,0.005835088,0.00009939919,0.00005536166,0.00001822882,0.0000995861,0.0001158492,0.002109402],"genre_scores_gemma":[0.9941624,0.000100789,0.003243779,0.0001136307,0.0000195639,0.00001492169,0.0004981517,0.00008532195,0.001761493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004421771,"threshold_uncertainty_score":0.01479232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07308241362478145,"score_gpt":0.3783289479065976,"score_spread":0.3052465342818161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}