{"id":"W4381664726","doi":"10.3390/ijms241210389","title":"Effect of Hesperidin on Barrier Function and Reactive Oxygen Species Production in an Oral Epithelial Cell Model, and on Secretion of Macrophage-Derived Inflammatory Mediators during Porphyromonas gingivalis Infection","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Universitetet i Oslo; Fundação de Amparo à Pesquisa do Estado de São Paulo; Justus Liebig Universität Gießen","keywords":"Porphyromonas gingivalis; Hesperidin; Reactive oxygen species; Secretion; Chemistry; Barrier function; Matrix metalloproteinase; Microbiology; Inflammation; Periodontitis; Cell biology; Immunology; Biology; Biochemistry; Medicine; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002670557,0.0003337089,0.0003889954,0.0002054268,0.0001609123,0.0002145444,0.0001161408,0.0002883471,0.0006611992],"category_scores_gemma":[0.0001979933,0.000121949,0.0002590629,0.0001710389,0.0001997821,0.0003339661,0.0001736787,0.0004832519,0.00009619482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001336156,"about_ca_system_score_gemma":0.0001525571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002771761,"about_ca_topic_score_gemma":0.0003042734,"domain_scores_codex":[0.9998449,0.00004123368,0.00002094915,0.00003082999,0.00003284722,0.00002918184],"domain_scores_gemma":[0.9998661,0.0000321933,0.00003311439,0.00001236927,0.00002700453,0.00002911758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00126519,0.0002928459,0.0002294054,0.0002091157,0.00001098043,0.0001041314,0.0000624535,0.00008128393,0.9948723,0.00003736866,0.00005239369,0.002782418],"study_design_scores_gemma":[0.00007168514,0.003798536,0.009081694,0.00001973573,0.00005007261,0.0002562799,0.0001269572,0.0009052864,0.9835433,0.00006767036,0.002064586,0.0000143191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956524,0.002946432,0.0005953561,0.00005997177,0.00004465445,0.00003490291,0.0001312723,0.0000204505,0.0005144985],"genre_scores_gemma":[0.9947599,0.001943116,0.001861503,0.00006150305,0.00002340456,0.00006608831,0.0001761915,0.000006163837,0.00110221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006611992,"threshold_uncertainty_score":0.002211928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361090352570148,"score_gpt":0.291608507685682,"score_spread":0.2779976041599805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}