{"id":"W4381666006","doi":"10.5267/j.ccl.2023.4.004","title":"Synthetic approaches, modification ability and biological activity of 1,3,4-thiadiazole based [5+5] annelated heterosystems: Mini-review","year":2023,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Thiazole; Bicyclic molecule; Broad spectrum; Imidazole; Combinatorial chemistry; Triazole; Stereochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001679596,0.0003615659,0.0003311662,0.0003833362,0.0001306933,0.0003286588,0.0003154237,0.0003452244,0.00129493],"category_scores_gemma":[0.000139867,0.0002090546,0.0002288612,0.0003395537,0.0001789012,0.0005150219,0.0001922972,0.0005367993,0.0003200358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000256068,"about_ca_system_score_gemma":0.0002438519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004568795,"about_ca_topic_score_gemma":0.0008286518,"domain_scores_codex":[0.9999388,0.000007160698,0.000007525346,0.00001632601,0.00001843535,0.00001171183],"domain_scores_gemma":[0.9999514,0.00001901449,0.00001342655,0.00000249297,0.00001018614,0.000003540597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001526451,0.000199692,0.0004308631,0.01988332,0.0001139425,0.0006449941,0.0002745012,0.002039179,0.5205309,0.01218286,0.0052939,0.4382533],"study_design_scores_gemma":[0.00002755307,0.001341554,0.002271716,0.000858544,0.0002254957,0.002706498,0.0001526538,0.001517056,0.3663672,0.001679145,0.622779,0.00007349839],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03305974,0.9564927,0.003500685,0.0002934433,0.0002244267,0.00004543375,0.0001398699,0.00004305222,0.006200738],"genre_scores_gemma":[0.08606455,0.9055272,0.003920893,0.0002618259,0.0001689622,0.00005388647,0.0002050592,0.00001014802,0.003787419],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00129493,"threshold_uncertainty_score":0.004332006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1281307400424681,"score_gpt":0.282950614797103,"score_spread":0.1548198747546349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}