{"id":"W4381682244","doi":"10.1016/j.cell.2023.05.039","title":"Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; National Heart, Lung, and Blood Institute; Israel National Road Safety Authority; American Heart Association","keywords":"Biology; Mitochondrial DNA; Cell biology; Mitochondrion; Innate immune system; Interferon; Genome instability; DNA damage; DNA; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266239,0.0002621056,0.0002122145,0.0001226504,0.0001074102,0.000211471,0.0001278785,0.0002402657,0.0008606637],"category_scores_gemma":[0.0000764006,0.00008217932,0.0001517143,0.00007835334,0.0001909502,0.0001740717,0.0002368041,0.0004750798,0.0002575036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002490829,"about_ca_system_score_gemma":0.0001114125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001767443,"about_ca_topic_score_gemma":0.000326578,"domain_scores_codex":[0.9998816,0.00001737603,0.000006811472,0.0000278701,0.00002925481,0.00003711651],"domain_scores_gemma":[0.9999075,0.00001068754,0.00003562791,0.000009077924,0.000008502332,0.00002868265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007903132,0.000009323988,0.0001991818,0.00001155144,0.000001555386,0.00002021014,0.000004274088,0.00002294435,0.9991002,0.00004384277,0.00001483559,0.0004929998],"study_design_scores_gemma":[0.00001119047,0.0002545549,0.008103132,0.000005032388,0.00000775902,0.0001720857,0.00003063252,0.0009356483,0.98953,0.00006211885,0.0008850282,0.000002668891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943935,0.001473082,0.003093039,0.0001043785,0.00002017225,0.00001077704,0.0001182503,0.00005365731,0.0007332203],"genre_scores_gemma":[0.9982519,0.0003177164,0.0006148417,0.00002729688,0.000004310365,0.000009507028,0.00009561134,0.000004640768,0.0006742888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008606637,"threshold_uncertainty_score":0.002879202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009628978409601634,"score_gpt":0.2278587244884459,"score_spread":0.2182297460788442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}