{"id":"W4381682244","doi":"10.1016/j.cell.2023.05.039","title":"Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; National Heart, Lung, and Blood Institute; Israel National Road Safety Authority; American Heart Association","keywords":"Biology; Mitochondrial DNA; Cell biology; Mitochondrion; Innate immune system; Interferon; Genome instability; DNA damage; DNA; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008973921,0.00009783448,0.0002131405,0.00005416562,0.00008519447,0.0000080776,0.00005741459,0.0001261462,0.0000886253],"category_scores_gemma":[0.00007511306,0.00008336586,0.00004671112,0.00008867418,0.000195421,0.00003085916,0.00006611554,0.0001255725,0.0002123516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009278248,"about_ca_system_score_gemma":0.00002930056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004247639,"about_ca_topic_score_gemma":0.000003419882,"domain_scores_codex":[0.999312,0.0001870698,0.0001455469,0.0001564794,0.00001700323,0.0001818769],"domain_scores_gemma":[0.9996389,0.0001342873,0.00004408802,0.0001239006,0.00004813477,0.00001074357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001786573,0.00002035488,0.00002675052,0.00001610295,0.0000470614,0.000002738442,0.0007124734,4.799693e-7,0.9786032,0.00001131542,0.01989959,0.0004812645],"study_design_scores_gemma":[0.0006647466,0.0002070496,0.0001771243,0.00001941714,0.00001493385,0.00001553214,0.0003490628,0.000008627639,0.9785532,0.000008717381,0.01989587,0.00008566157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958727,0.001339476,0.000056943,0.00007644029,0.0005264592,0.0001610809,0.00004404008,0.00004683878,0.00187601],"genre_scores_gemma":[0.9868586,0.00007703893,0.0000312316,0.0000325314,0.00001888821,0.000001946237,0.00005049506,0.000009933777,0.01291935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01104334,"threshold_uncertainty_score":0.3399561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009628978409601634,"score_gpt":0.2278587244884459,"score_spread":0.2182297460788442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}