{"id":"W4381682806","doi":"10.1172/jci166248","title":"Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Institutes of Health; National Institute of General Medical Sciences; Northwestern University; National Cancer Institute; Prostate Cancer Foundation","keywords":"Cell biology; Mitosis; Aurora A kinase; Aurora kinase; Biology; Cancer research; Microtubule; Mitotic catastrophe; Kinase; Aurora inhibitor; Signal transduction; Cell cycle; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007486471,0.0001734155,0.0001360243,0.0002229323,0.0001587337,0.0002038273,0.00007014328,0.0001102064,0.002197699],"category_scores_gemma":[0.00008598746,0.00007974917,0.0002120511,0.000100077,0.0001266933,0.00009658935,0.000205503,0.0003199549,0.0004246973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002525758,"about_ca_system_score_gemma":0.0002521358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008741853,"about_ca_topic_score_gemma":0.00192175,"domain_scores_codex":[0.9998732,0.00002930463,0.00000560133,0.00001374268,0.00003617055,0.00004204212],"domain_scores_gemma":[0.9999441,0.000004820501,0.00001544504,0.000003937441,0.000008546308,0.00002308317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002197872,0.00003955793,0.004900538,0.0001021053,0.00002596983,0.0003363292,0.00002146171,0.0000928037,0.9872698,0.0002850378,0.0004933875,0.006213329],"study_design_scores_gemma":[0.0001221274,0.001349393,0.2674475,0.00004143751,0.0000956995,0.007040202,0.0002383541,0.002914331,0.6911461,0.0003282705,0.02925164,0.00002487364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864883,0.007535867,0.0008242601,0.0002820201,0.0000428518,0.00002539711,0.0003256601,0.00009463089,0.004381184],"genre_scores_gemma":[0.997077,0.001120555,0.00028073,0.00004271732,0.00001228014,0.00001042998,0.0001931301,0.000006129653,0.001257095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002197699,"threshold_uncertainty_score":0.007352054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04203198433666636,"score_gpt":0.3437467991179001,"score_spread":0.3017148147812337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}