{"id":"W4381682806","doi":"10.1172/jci166248","title":"Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Institutes of Health; National Institute of General Medical Sciences; Northwestern University; National Cancer Institute; Prostate Cancer Foundation","keywords":"Cell biology; Mitosis; Aurora A kinase; Aurora kinase; Biology; Cancer research; Microtubule; Mitotic catastrophe; Kinase; Aurora inhibitor; Signal transduction; Cell cycle; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007197654,0.0001188765,0.0002512639,0.00006338338,0.00005493332,0.00003747683,0.0001017155,0.00007407236,0.00004342503],"category_scores_gemma":[0.001506089,0.00009400624,0.0001082465,0.000168814,0.0001010326,0.00001987383,0.00006196242,0.0002184378,0.000004153474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006526378,"about_ca_system_score_gemma":0.0001240206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009215706,"about_ca_topic_score_gemma":0.000001963216,"domain_scores_codex":[0.9986424,0.0001304214,0.0006834582,0.0002034501,0.0001779851,0.0001623213],"domain_scores_gemma":[0.9988586,0.00007667422,0.0005200789,0.00009296781,0.0002542201,0.0001974081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001710449,0.00003245198,0.01738034,0.00003941317,0.0000534936,0.00001263063,0.00004357489,0.00003077415,0.9704703,0.00007918401,0.003221552,0.008465217],"study_design_scores_gemma":[0.0009537999,0.0008863056,0.007874401,0.0000998801,0.00003327479,0.00002397847,0.00004114149,0.0003866756,0.981221,0.002798063,0.005549867,0.000131568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952031,0.0002435741,0.00008167427,0.003854123,0.0004638404,0.0001216657,0.000007596567,0.00001160132,0.00001284295],"genre_scores_gemma":[0.9942203,0.002326136,0.00159101,0.0005070664,0.0009453286,0.000008440953,0.00003114101,0.00002356234,0.0003470532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01075072,"threshold_uncertainty_score":0.3833463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04203198433666636,"score_gpt":0.3437467991179001,"score_spread":0.3017148147812337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}