{"id":"W4381686492","doi":"10.1186/s12964-023-01171-8","title":"Islets in the body are never flat: transitioning from two-dimensional (2D) monolayer culture to three-dimensional (3D) spheroid for better efficiency in the generation of functional hPSC-derived pancreatic β cells in vitro","year":2023,"lang":"en","type":"review","venue":"Cell Communication and Signaling","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Qatar National Library; Qatar Biomedical Research Institute, Hamad Bin Khalifa University","keywords":"Progenitor cell; Cell biology; Biology; Transplantation; Cell therapy; Cell culture; Cell; Stem cell; In vivo; Pancreatic islets; Regeneration (biology); Islet; Insulin; Cancer research; Medicine; Internal medicine; Endocrinology; Biotechnology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001944946,0.0002371486,0.0003280841,0.0002391846,0.0003068109,0.001014486,0.0001877623,0.00034044,0.001050537],"category_scores_gemma":[0.0001443781,0.0002691767,0.0003733556,0.0002915332,0.000281551,0.0005292385,0.0004455177,0.001004227,0.00081271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885276,"about_ca_system_score_gemma":0.0002458861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006569148,"about_ca_topic_score_gemma":0.001010351,"domain_scores_codex":[0.9998617,0.00001505588,0.00001494254,0.00003430828,0.00005460636,0.00001938139],"domain_scores_gemma":[0.9999202,0.00001251177,0.00001204046,0.0000149908,0.0000175701,0.00002271191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000101098,0.00006468862,0.0006382602,0.0003023303,0.00001555253,0.0004112639,0.0002781099,0.0008687344,0.9684666,0.001615307,0.001966918,0.02527113],"study_design_scores_gemma":[0.00005767497,0.0004792152,0.01010231,0.0001778845,0.0001382685,0.001773627,0.0004507279,0.007065962,0.8544041,0.00174186,0.1235061,0.0001023122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7261996,0.04511701,0.1818833,0.002748567,0.002644636,0.000541991,0.002793955,0.002725504,0.03534542],"genre_scores_gemma":[0.8743604,0.02527687,0.08720578,0.0011576,0.0002091971,0.0003834361,0.00285571,0.0004634819,0.008087695],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001050537,"threshold_uncertainty_score":0.003514349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06572514268313809,"score_gpt":0.292632606784882,"score_spread":0.2269074641017439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}