{"id":"W4381715051","doi":"10.1158/1535-7163.mct-23-0041","title":"A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Juravinski Cancer Centre; BC Children's Hospital; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Glutamine; GPX4; Lipid peroxidation; Glutathione; Biochemistry; Metabolism; Homeostasis; Chemistry; Cell biology; Glutathione peroxidase; Biology; Enzyme; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007348559,0.0001785406,0.0001501173,0.0001238568,0.0001561569,0.0001928006,0.0001000881,0.0001940852,0.001048951],"category_scores_gemma":[0.00004830928,0.00006383766,0.0001388982,0.00008016059,0.0001641313,0.00009658898,0.0001296467,0.0002391842,0.0001397196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003972726,"about_ca_system_score_gemma":0.000277806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001456833,"about_ca_topic_score_gemma":0.002590116,"domain_scores_codex":[0.9999431,0.000008744839,0.000003765114,0.00001246591,0.00001633746,0.00001552475],"domain_scores_gemma":[0.9999641,0.000003186032,0.00001214242,0.00000205129,0.00000565451,0.00001283347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006868634,0.000007441294,0.0004323093,0.00002139702,0.000003866719,0.00005879067,0.0000095981,0.00005822328,0.9979729,0.0001450782,0.00007578012,0.001146014],"study_design_scores_gemma":[0.00003158534,0.0003101132,0.02845331,0.0000105243,0.00003564039,0.0004106238,0.000112038,0.002652481,0.9609575,0.0002037537,0.006815137,0.000007373872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902971,0.002877521,0.003749467,0.0003072521,0.00004336688,0.00003426986,0.0003266872,0.000137892,0.002226415],"genre_scores_gemma":[0.9967567,0.0005465763,0.0007605734,0.00006305011,0.000004445953,0.00001525157,0.0001734243,0.000007307279,0.001672789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001456833,"threshold_uncertainty_score":0.003509104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471078403572883,"score_gpt":0.2607522654575003,"score_spread":0.2460414814217715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}