{"id":"W4381715176","doi":"10.1002/cmdc.202300207","title":"Queuine Analogues Incorporating the 7‐Aminomethyl‐7‐deazaguanine Core: Structure–Activity Relationships in the Treatment of Experimental Autoimmune Encephalomyelitis","year":2023,"lang":"en","type":"article","venue":"ChemMedChem","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Irish Cancer Society; Enterprise Ireland","keywords":"Experimental autoimmune encephalomyelitis; Transfer RNA; Encephalomyelitis; Stereochemistry; Chemistry; Multiple sclerosis; Biology; Biochemistry; Immunology; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319852,0.0002886249,0.0003056906,0.0002317125,0.0001000937,0.0001744671,0.0001451258,0.0003133624,0.001121106],"category_scores_gemma":[0.00008915376,0.000111172,0.0001757959,0.0001830294,0.0001050328,0.0001191542,0.0001090912,0.0004521695,0.0001533529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001814579,"about_ca_system_score_gemma":0.000136687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005093357,"about_ca_topic_score_gemma":0.002236867,"domain_scores_codex":[0.9999601,0.000008699538,0.000003509337,0.000007688304,0.000009577288,0.00001058982],"domain_scores_gemma":[0.9999474,0.00001176233,0.00001026338,0.000003408627,0.000008534217,0.00001856032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001023462,0.0002466588,0.0001907572,0.0001258661,0.00002731927,0.00009570749,0.00004221236,0.001225489,0.9823706,0.0002031107,0.0001019917,0.01434692],"study_design_scores_gemma":[0.0007144107,0.02324136,0.006295874,0.0000390732,0.0001392646,0.000352953,0.0000327901,0.00182742,0.9586418,0.0001454997,0.008542609,0.00002700208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898901,0.006475097,0.0009658131,0.00006168622,0.00002142779,0.00008441998,0.0002341607,0.00004541773,0.00222179],"genre_scores_gemma":[0.9909559,0.004984761,0.001338792,0.000049089,0.00001163486,0.00003823602,0.0003834605,0.00001100914,0.002227206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121106,"threshold_uncertainty_score":0.003750443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06060042504289014,"score_gpt":0.3053919159822928,"score_spread":0.2447914909394026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}