{"id":"W4381716537","doi":"10.1056/nejmoa2302392","title":"Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":418,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; York University","funders":"Eli Lilly and Company","keywords":"Medicine; Placebo; Weight loss; Overweight; Body mass index; Weight change; Obesity; Randomization; Clinical endpoint; Internal medicine; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000804803,0.000539023,0.001237772,0.0002657819,0.0002506581,0.0003027349,0.0003463957,0.0008433826,0.004539531],"category_scores_gemma":[0.0006904659,0.000228775,0.000601409,0.0002159589,0.0002685486,0.0004804172,0.0002777785,0.001232467,0.0005910762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001799666,"about_ca_system_score_gemma":0.0004172022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002857186,"about_ca_topic_score_gemma":0.0008051398,"domain_scores_codex":[0.99977,0.00009897047,0.00002650728,0.0000400008,0.00003205202,0.00003247985],"domain_scores_gemma":[0.9997,0.00007694832,0.00009550361,0.00001551232,0.00002297172,0.00008917014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6962812,0.01988299,0.005849546,0.003870145,0.001294136,0.0002391572,0.0001619046,0.0005215797,0.02624484,0.0001965323,0.005707378,0.2397506],"study_design_scores_gemma":[0.7170834,0.2546507,0.01829363,0.0003217518,0.0008098746,0.0004148911,0.00008631843,0.0006352851,0.002326895,0.0001689891,0.005179022,0.00002926983],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729811,0.0201145,0.0007751323,0.0008236806,0.0004049114,0.001766864,0.0006688274,0.0001474529,0.002317605],"genre_scores_gemma":[0.9822744,0.008182189,0.002345602,0.001711233,0.0004709339,0.002566956,0.0007281898,0.00001730406,0.001703141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004539531,"threshold_uncertainty_score":0.01518619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788968060431937,"score_gpt":0.2679620818097543,"score_spread":0.2500724012054349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}