{"id":"W4381716537","doi":"10.1056/nejmoa2302392","title":"Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":418,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; York University","funders":"Eli Lilly and Company","keywords":"Medicine; Placebo; Weight loss; Overweight; Body mass index; Weight change; Obesity; Randomization; Clinical endpoint; Internal medicine; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000693762,0.0001695178,0.0005210908,0.0002262399,0.00006604116,0.00001094269,0.00009965636,0.0000457088,0.0001872116],"category_scores_gemma":[0.000190263,0.00009338897,0.00008026567,0.0002781705,0.00007232851,0.00009088027,0.00001973706,0.0001578397,0.00002630637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006849253,"about_ca_system_score_gemma":0.0001187567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004644302,"about_ca_topic_score_gemma":0.00004982757,"domain_scores_codex":[0.9987308,0.00002524465,0.0003603426,0.0001502845,0.0004559858,0.0002773445],"domain_scores_gemma":[0.9989668,0.0000992463,0.0002287225,0.0001639118,0.0002167827,0.0003245155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01109064,0.0003182829,0.03615867,0.0004563872,0.0006811244,0.0004614386,0.002203042,0.00001592306,0.0009854449,0.0003742575,0.4342082,0.5130466],"study_design_scores_gemma":[0.1903178,0.0211102,0.02750931,0.002003091,0.001363909,0.0001790706,0.001325043,0.0001263648,0.0007628042,0.0004011921,0.7546961,0.0002050788],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737418,0.000536234,0.0005816892,0.02118839,0.0008782219,0.0006710391,0.000006563444,0.00006473003,0.002331287],"genre_scores_gemma":[0.9737833,0.0006783108,0.004276652,0.0009052241,0.005304056,0.0000135984,0.0001470349,0.00004593985,0.01484588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5128415,"threshold_uncertainty_score":0.3808292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788968060431937,"score_gpt":0.2679620818097543,"score_spread":0.2500724012054349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}