{"id":"W4381716540","doi":"10.1371/journal.ppat.1011455","title":"XIAP promotes the expansion and limits the contraction of CD8 T cell response through cell extrinsic and intrinsic mechanisms respectively","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"XIAP; Cytotoxic T cell; Cell biology; CD8; Inhibitor of apoptosis; Priming (agriculture); T cell; Biology; Secretion; Effector; Immunology; Programmed cell death; Cancer research; Apoptosis; Antigen; Immune system; Biochemistry; In vitro; Caspase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331424,0.0002079969,0.0001227594,0.0001401817,0.00007265356,0.0002348613,0.0001175033,0.0001883235,0.001231937],"category_scores_gemma":[0.0001769858,0.00006800292,0.0001154058,0.0000699525,0.0001462096,0.0001704887,0.0003042815,0.0004828702,0.0002633977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000140666,"about_ca_system_score_gemma":0.0000999816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005129252,"about_ca_topic_score_gemma":0.00009352838,"domain_scores_codex":[0.9998888,0.0000297729,0.000009180268,0.00001798424,0.0000157252,0.00003848497],"domain_scores_gemma":[0.999898,0.00001885584,0.00002506297,0.00001459845,0.000009865343,0.00003365459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004363894,0.00005143845,0.001771133,0.00008228311,0.000006451786,0.0002812095,0.00004542947,0.00010549,0.9859098,0.0004437061,0.0001543755,0.01071223],"study_design_scores_gemma":[0.0001071794,0.001353597,0.03317275,0.00004210289,0.00003609379,0.003032555,0.00009594401,0.002180806,0.9459629,0.0004721715,0.01353646,0.000007500689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930933,0.003134518,0.001545839,0.0000826114,0.00002148669,0.00001639506,0.00005892574,0.00003807813,0.002008979],"genre_scores_gemma":[0.9979123,0.0004384821,0.0005274451,0.00002209526,0.00001781982,0.00001781082,0.00004747975,0.000004533737,0.00101186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231937,"threshold_uncertainty_score":0.004121244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02439343817910671,"score_gpt":0.2326085537147313,"score_spread":0.2082151155356246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}