{"id":"W4381716540","doi":"10.1371/journal.ppat.1011455","title":"XIAP promotes the expansion and limits the contraction of CD8 T cell response through cell extrinsic and intrinsic mechanisms respectively","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"XIAP; Cytotoxic T cell; Cell biology; CD8; Inhibitor of apoptosis; Priming (agriculture); T cell; Biology; Secretion; Effector; Immunology; Programmed cell death; Cancer research; Apoptosis; Antigen; Immune system; Biochemistry; In vitro; Caspase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005758256,0.0001672323,0.0002031532,0.00009895229,0.00042961,0.00002484314,0.0001046376,0.0001687416,0.00009699521],"category_scores_gemma":[0.0002499193,0.0001025139,0.00006286638,0.0002415435,0.0001839299,0.0001431769,0.00008674045,0.0003480732,0.0001729847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002534394,"about_ca_system_score_gemma":0.00003634395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002949464,"about_ca_topic_score_gemma":0.000004639519,"domain_scores_codex":[0.9984798,0.0006643775,0.0002721115,0.0002916778,0.00006190241,0.0002301006],"domain_scores_gemma":[0.9984614,0.0009140917,0.0001977238,0.0002971252,0.0001160928,0.00001356555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001239928,0.0001090933,0.00006725219,0.00002256024,0.00004518539,0.000003217298,0.002809243,0.000001379093,0.9931093,0.0003350229,0.0009499199,0.001307923],"study_design_scores_gemma":[0.000840157,0.0005132924,0.007977737,0.00003234977,0.00009095155,0.00004949262,0.00445089,0.00003874595,0.9790445,0.0004663322,0.006374947,0.000120597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954657,0.001406686,0.0001547221,0.000917812,0.0008522829,0.0005217848,0.00001444219,0.00008882528,0.0005777639],"genre_scores_gemma":[0.9946331,0.0009036593,0.00003360721,0.0001612563,0.0000251464,0.00004269669,0.0000197243,0.00002073445,0.004160098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01406477,"threshold_uncertainty_score":0.4180396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02439343817910671,"score_gpt":0.2326085537147313,"score_spread":0.2082151155356246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}