{"id":"W4381741633","doi":"10.2337/db23-836-p","title":"836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial","year":2023,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Insulin; Hypoglycemia; Internal medicine; Diabetes mellitus; Clinical trial; Type 2 diabetes; Endocrinology; Type 1 diabetes; Islet; Gastroenterology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001430723,0.0004697809,0.001005962,0.0002033164,0.000182476,0.0001535333,0.0006091138,0.0004218826,0.000413351],"category_scores_gemma":[0.001477208,0.0003391224,0.0001157966,0.0009130826,0.0002551283,0.0003104783,0.000615457,0.0008683923,0.0006703294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005940103,"about_ca_system_score_gemma":0.0002012384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002821168,"about_ca_topic_score_gemma":0.00006327386,"domain_scores_codex":[0.9954306,0.0006743039,0.00111637,0.001369847,0.0007199217,0.0006889314],"domain_scores_gemma":[0.9957687,0.001757044,0.0003469724,0.001662268,0.000189534,0.0002755192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009252019,0.00162924,0.4259398,0.0001322788,0.0008311247,0.00004309781,0.0007909051,0.00002499118,0.506051,0.000005317374,0.02845463,0.02684555],"study_design_scores_gemma":[0.04845481,0.001684432,0.5401065,0.0006488871,0.001054219,6.361491e-7,0.001534225,0.01457337,0.3875306,0.0004533661,0.002966808,0.0009921403],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889489,0.004061761,0.000003157386,0.001092649,0.003373348,0.001329812,0.0007325849,0.0003784522,0.00007933257],"genre_scores_gemma":[0.9911984,0.002268858,0.0001010452,0.0006852049,0.001155217,0.00007230786,0.004099874,0.0000731242,0.0003460209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1185204,"threshold_uncertainty_score":0.9999061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0656500450310883,"score_gpt":0.2982954500483205,"score_spread":0.2326454050172322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}