{"id":"W4381741633","doi":"10.2337/db23-836-p","title":"836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial","year":2023,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Insulin; Hypoglycemia; Internal medicine; Diabetes mellitus; Clinical trial; Type 2 diabetes; Endocrinology; Type 1 diabetes; Islet; Gastroenterology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001785674,0.000726509,0.0009708054,0.0002156061,0.0002481804,0.001161626,0.0004845841,0.0007837071,0.004307266],"category_scores_gemma":[0.001105682,0.000171511,0.0009871493,0.0004737926,0.0004181257,0.0009624752,0.0002926543,0.003037707,0.000859737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002868377,"about_ca_system_score_gemma":0.0006489683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003001873,"about_ca_topic_score_gemma":0.0005752213,"domain_scores_codex":[0.9996278,0.0001745702,0.00002408276,0.00003816106,0.00007932344,0.0000559676],"domain_scores_gemma":[0.9994373,0.0001810058,0.0001082399,0.0000517371,0.00004363878,0.0001782245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6085178,0.01034263,0.006256665,0.001898987,0.00189191,0.0004549967,0.0001425199,0.002186244,0.01495857,0.001014442,0.02667044,0.3256647],"study_design_scores_gemma":[0.7337781,0.1936988,0.03130263,0.0003575262,0.001484631,0.00125482,0.00007039413,0.001989914,0.00418732,0.001717976,0.03008221,0.00007564477],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9312771,0.0256554,0.00283427,0.002865001,0.0009715778,0.001774645,0.01007023,0.0003179291,0.02423371],"genre_scores_gemma":[0.9457232,0.019009,0.003218771,0.004449502,0.0008851875,0.001991195,0.01727249,0.0001144883,0.007336311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004307266,"threshold_uncertainty_score":0.01440924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0656500450310883,"score_gpt":0.2982954500483205,"score_spread":0.2326454050172322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}