{"id":"W4381846259","doi":"10.3389/fimmu.2023.1171103","title":"The transcriptome response of astronaut leukocytes to long missions aboard the International Space Station reveals immune modulation","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Spaceflight effects on biology","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Space Agency","keywords":"Spaceflight; Transcriptome; International Space Station; Immune system; Biology; Downregulation and upregulation; Gene; Weightlessness; Gene expression; Fold change; Housekeeping gene; Computational biology; Immunology; Genetics; Physics; Aeronautics; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001155928,0.0001625623,0.0002205075,0.0003084827,0.0003104066,0.0004182158,0.0001052461,0.000228787,0.001237856],"category_scores_gemma":[0.0002094659,0.00008831143,0.0001907404,0.0004060633,0.0002006113,0.000147472,0.0002460163,0.0002413708,0.0002511233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002056908,"about_ca_system_score_gemma":0.0002004342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001403141,"about_ca_topic_score_gemma":0.002008844,"domain_scores_codex":[0.9999129,0.000007670227,0.000003717873,0.00003277304,0.00001966121,0.00002336354],"domain_scores_gemma":[0.9998779,0.00001697102,0.00004111536,0.000008803997,0.00003112911,0.00002406481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000731032,0.00004757254,0.2055469,0.00008156717,0.00005039711,0.000117108,0.0006166065,0.0002362404,0.783337,0.00006821545,0.0001492605,0.009018121],"study_design_scores_gemma":[0.000004505934,0.0002564825,0.9835661,0.000008991424,0.00002609219,0.0001095369,0.0005629417,0.0003550317,0.01448373,0.00004965572,0.0005706131,0.000006294092],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998866,0.0001639988,0.0003435214,0.00001518832,0.0000029621,0.000004995019,0.0003812614,0.00000569361,0.0002163278],"genre_scores_gemma":[0.9973714,0.0002028354,0.0006029357,0.00004252428,0.00000866615,0.0000307247,0.001057199,0.000004540744,0.0006790855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001403141,"threshold_uncertainty_score":0.004141092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207909475772442,"score_gpt":0.2817423843334835,"score_spread":0.2696632895757591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}