{"id":"W4381847846","doi":"10.1016/j.isci.2023.107198","title":"Daughter cell fate choice instructed preemptively by mother cells facing nutrient limitation","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Zhejiang University; Wuhan University School of Medicine; National Natural Science Foundation of China; National Key Research and Development Program of China Stem Cell and Translational Research; BC Children's Hospital; Children's Hospital of Philadelphia","keywords":"Glutamine; Daughter; Cell division; Cell biology; Cell cycle; Nutrient; Cell fate determination; Asymmetric cell division; Biology; Amino acid; Cell; Chemistry; Biochemistry; Evolutionary biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577386,0.00009584493,0.00006129051,0.00004844265,0.0001023592,0.00004291034,0.0001654737,0.00007318988,0.000009009097],"category_scores_gemma":[0.00004340151,0.00008990557,0.00003187457,0.0002773715,0.00006535403,0.000008786065,0.00007720647,0.00004522791,0.00007891597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001051298,"about_ca_system_score_gemma":0.00002737774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001865003,"about_ca_topic_score_gemma":0.000007562682,"domain_scores_codex":[0.9991109,0.00003546872,0.0001321036,0.0003339199,0.0001705238,0.0002170613],"domain_scores_gemma":[0.9996025,0.00001784042,0.00007118942,0.0001877349,0.0000608098,0.00005990814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003803795,0.00001568219,0.001628302,0.000005942168,0.000002156896,3.194648e-7,0.0001465879,0.0004153863,0.9943363,0.00000730758,0.0014664,0.001971817],"study_design_scores_gemma":[0.0002012391,0.00006698508,0.007703919,0.000004734323,0.000003047961,1.455969e-7,0.00005305386,0.0009339491,0.9403756,0.00008102484,0.05045606,0.0001202963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989657,0.0003558203,0.007914945,0.00007239058,0.0001502639,0.0001363441,0.00002842091,0.00002267901,0.001662093],"genre_scores_gemma":[0.9951707,0.0002124831,0.0007302547,0.00007396139,0.00005497578,0.00001170306,0.00008224449,0.00001237614,0.003651345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05396075,"threshold_uncertainty_score":0.3666243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0149856106849473,"score_gpt":0.2529745950624948,"score_spread":0.2379889843775475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}