{"id":"W4381855175","doi":"10.1177/20406207231177282","title":"Treating accelerated and blast phase myeloproliferative neoplasms: progress and challenges","year":2023,"lang":"en","type":"review","venue":"Therapeutic Advances in Hematology","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sierra Oncology; National Cancer Institute; Galecto; Incyte; Servier; Celgene","keywords":"Medicine; Myelofibrosis; Essential thrombocythemia; Polycythemia vera; Bone marrow; Internal medicine; Myeloid leukemia; Myeloproliferative neoplasm; Oncology; Population; Myeloid; Acute leukemia; Haematopoiesis; Leukemia; Immunology; Stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002499624,0.0008592476,0.003795922,0.0004632942,0.0001402859,0.00003961061,0.0001152931,0.0004777361,0.00003608828],"category_scores_gemma":[0.00008550989,0.0006077031,0.0001447911,0.0004367064,0.0005094393,0.0001686038,0.0001195959,0.0005463269,0.00002959979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113979,"about_ca_system_score_gemma":0.0002119686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003241206,"about_ca_topic_score_gemma":0.00009211721,"domain_scores_codex":[0.9967388,0.0003725153,0.0009922836,0.001069545,0.0002119949,0.0006148904],"domain_scores_gemma":[0.9975371,0.001368702,0.0004560894,0.0003548561,0.00008949718,0.0001937184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001487775,0.000455922,0.0005999783,0.02110151,0.0006296039,0.0005097332,0.0008328973,2.260515e-7,1.334716e-7,0.009505404,0.000003110926,0.9662127],"study_design_scores_gemma":[0.01049667,0.003432743,0.0001600846,0.04541438,0.002979521,0.006226661,0.001217997,0.0002501434,0.0000562539,0.00307398,0.9252795,0.00141206],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008935349,0.9952183,0.000008945384,0.0005460567,0.0001331734,0.002687521,0.00003684026,0.0001488565,0.000326789],"genre_scores_gemma":[0.0009677737,0.9957309,0.0005674763,0.00008028285,0.000101548,0.002266001,0.00009679278,0.0001251377,0.00006410274],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9648007,"threshold_uncertainty_score":0.9996374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.170944473417937,"score_gpt":0.4451018780176871,"score_spread":0.2741574045997501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}