{"id":"W4381885413","doi":"10.1016/s0140-6736(23)01163-7","title":"Efficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":297,"is_retracted":false,"has_abstract":false,"ca_institutions":"LMC Diabetes & Endocrinology (Canada)","funders":"Steno Diabetes Center Copenhagen","keywords":"Semaglutide; Medicine; Type 2 diabetes; Clinical endpoint; Internal medicine; Randomized controlled trial; Adverse effect; Intention-to-treat analysis; Exenatide; Diabetes mellitus; Dulaglutide; Physical therapy; Liraglutide; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002226748,0.002245238,0.004863975,0.0005708051,0.000472141,0.001615592,0.001369202,0.003174152,0.005904802],"category_scores_gemma":[0.001772987,0.001152231,0.002834021,0.0005320612,0.001490196,0.001679197,0.0005259131,0.004382224,0.001509404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001098443,"about_ca_system_score_gemma":0.001055288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001302759,"about_ca_topic_score_gemma":0.002061409,"domain_scores_codex":[0.9990869,0.000409874,0.00005078619,0.0002263192,0.00007604637,0.0001501266],"domain_scores_gemma":[0.9989893,0.0002602876,0.0002284538,0.0000913116,0.00005981688,0.0003708705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9866713,0.002736014,0.0003061552,0.0003084037,0.0006976736,0.00002174418,0.00002626719,0.0001257364,0.001787483,0.00003978794,0.0003676015,0.006911813],"study_design_scores_gemma":[0.9689524,0.02903766,0.001058166,0.00001844429,0.0003462913,0.00001927895,0.00001151071,0.0001866844,0.0001598771,0.00005017786,0.0001463423,0.00001323872],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884174,0.006436068,0.0004412328,0.0006890536,0.0006948149,0.0009730163,0.0006305007,0.0001700309,0.00154781],"genre_scores_gemma":[0.9878381,0.002745837,0.001366175,0.001476223,0.0006215092,0.00163642,0.0009891969,0.0000560755,0.003270347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005904802,"threshold_uncertainty_score":0.01975352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05563561283814931,"score_gpt":0.33893580047556,"score_spread":0.2833001876374107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}