{"id":"W4381889482","doi":"10.1016/j.yexcr.2023.113687","title":"Cathepsin-K inhibition enhances anti-cancerous activity within oral squamous cell carcinoma cells: Uncloaking the potency of new K21 formulation","year":2023,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"International Medical University","keywords":"Biology; Fibroblast; Cell culture; Cell; Cancer cell; Wound healing; Molecular biology; Cancer; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009574833,0.0002354241,0.0002186076,0.0001070376,0.0001001834,0.0002299062,0.0001496395,0.0002259871,0.001051372],"category_scores_gemma":[0.000101256,0.00007659238,0.0002628634,0.0000937232,0.0001587726,0.0002315987,0.0001215903,0.0002959467,0.0002197102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001814676,"about_ca_system_score_gemma":0.0001493865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002757343,"about_ca_topic_score_gemma":0.0005258367,"domain_scores_codex":[0.9999195,0.0000109546,0.00000996486,0.00001653942,0.00002527339,0.00001762876],"domain_scores_gemma":[0.9999489,0.000008492731,0.00001732812,0.000006789399,0.000009808065,0.000008852175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001157638,0.00003984867,0.00009976851,0.00007679743,0.00000534651,0.00003321828,0.000009835049,0.00007103413,0.9982222,0.00003269798,0.00003790255,0.001255507],"study_design_scores_gemma":[0.000009231153,0.0004502304,0.0007670025,0.000003989706,0.00001227637,0.00009539757,0.00001016263,0.0002383297,0.9974003,0.000008397809,0.001002031,0.000002654863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996213,0.001753725,0.0009828119,0.00007478357,0.00002772918,0.00001925567,0.0001134093,0.00002881097,0.0007864996],"genre_scores_gemma":[0.9961377,0.001283894,0.001110924,0.00002458142,0.000006181569,0.00001767551,0.0001368312,0.000009255948,0.001272919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001051372,"threshold_uncertainty_score":0.003517151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05452081460788949,"score_gpt":0.3462600126813719,"score_spread":0.2917391980734824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}