{"id":"W4381890138","doi":"10.1101/2023.06.20.545790","title":"Engineered CD47 protects T cells for enhanced antitumor immunity","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"School of Medicine, Stanford University; Virginia and D.K. Ludwig Fund for Cancer Research; Alliance Nationale pour les Sciences de la Vie et de la Santé; Parker Institute for Cancer Immunotherapy; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"CD47; Chimeric antigen receptor; Macrophage; Immune system; T cell; Cancer research; Adoptive cell transfer; Immunology; Cell biology; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001438165,0.0007838139,0.001216944,0.0006655432,0.000211394,0.000195157,0.0007424373,0.0008109921,0.0003710109],"category_scores_gemma":[0.0008324329,0.0008333826,0.0004841418,0.0008918867,0.0001690805,0.00009459862,0.0006462944,0.001861079,0.0002929721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006260716,"about_ca_system_score_gemma":0.001549023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001120295,"about_ca_topic_score_gemma":0.000003688918,"domain_scores_codex":[0.995837,0.0001600379,0.0007381223,0.00130427,0.0007976979,0.001162907],"domain_scores_gemma":[0.9951457,0.0002603072,0.0003258574,0.002558972,0.001173725,0.0005354609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004236747,0.0002430409,0.00009405916,0.002714709,0.0004348198,0.00009954299,0.00001953077,0.00005918276,0.9950601,0.00005545552,0.0007884511,0.000007427097],"study_design_scores_gemma":[0.002091243,0.0003018853,0.00828154,0.001002426,0.0001570662,2.836981e-8,0.000004648931,0.0005786809,0.9786348,0.000003422982,0.008183641,0.0007606665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791533,0.0005676949,0.006886773,0.0004528506,0.00225988,0.008509451,0.0005877511,0.001549266,0.00003299273],"genre_scores_gemma":[0.9866613,0.0004470339,0.00776371,0.0001273806,0.001199752,0.002656358,0.000003025988,0.0005143074,0.0006271424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01642536,"threshold_uncertainty_score":0.9994117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03349499980653457,"score_gpt":0.2778376257972385,"score_spread":0.2443426259907039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}