{"id":"W4381890253","doi":"10.1101/2023.06.19.544278","title":"Human iPSC 4R tauopathy model uncovers modifiers of tau propagation","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Weill Cornell Medical College; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; University of Pennsylvania","keywords":"Tauopathy; Tangle; Tau protein; Neuroscience; Induced pluripotent stem cell; Biology; Phenotype; Cell biology; Gene; Neurodegeneration; Genetics; Alzheimer's disease; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002414007,0.0005185061,0.0003717824,0.0005084058,0.0001833612,0.0003375957,0.0002650248,0.0005318875,0.002056474],"category_scores_gemma":[0.0001200259,0.0001455343,0.0004429999,0.0001747657,0.0002919056,0.0002128443,0.0003102692,0.000810104,0.0006420384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003056955,"about_ca_system_score_gemma":0.0001940839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006284269,"about_ca_topic_score_gemma":0.0004415182,"domain_scores_codex":[0.9998487,0.00001425339,0.00001554831,0.00004429893,0.00005440314,0.00002280465],"domain_scores_gemma":[0.9999136,0.0000186237,0.00002444374,0.00001727138,0.00001153136,0.00001455975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009059308,0.00002762469,0.0002271257,0.00003964911,0.00001106746,0.0001747802,0.0000153219,0.0003200747,0.9964395,0.0002931257,0.0001685784,0.002192531],"study_design_scores_gemma":[0.00001049282,0.00008624266,0.001255045,0.00001103212,0.00003786841,0.0004332727,0.00001579262,0.002092234,0.9923367,0.0002318843,0.003482937,0.000006401078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586903,0.002303526,0.02729608,0.0003116936,0.0001661124,0.0001045338,0.003191632,0.000826543,0.007109635],"genre_scores_gemma":[0.9740846,0.001512053,0.01339751,0.0002002339,0.00002711469,0.0001098596,0.003256737,0.0001579452,0.007253947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002056474,"threshold_uncertainty_score":0.006879628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04381756770798527,"score_gpt":0.2899393662746191,"score_spread":0.2461217985666338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}