{"id":"W4381893311","doi":"10.1016/j.jpsychires.2023.06.028","title":"Arketamine for bipolar depression: Open-label, dose-escalation, pilot study","year":2023,"lang":"en","type":"article","venue":"Journal of Psychiatric Research","topic":"Treatment of Major Depression","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Bipolar disorder; Depression (economics); Rating scale; Major depressive disorder; Antidepressant; Psychology; Bipolar II disorder; Major depressive episode; Hamilton Rating Scale for Depression; Ketamine; Treatment-resistant depression; Medicine; Internal medicine; Psychiatry; Mood","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006073711,0.0001844322,0.0005299243,0.001638349,0.0004166996,0.0001424986,0.000693456,0.00007866736,0.0001400391],"category_scores_gemma":[0.001153906,0.0001248648,0.00009358743,0.002374944,0.0000559092,0.0002794957,0.0003090294,0.0007219008,0.0001127352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001477795,"about_ca_system_score_gemma":0.0004783424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003848566,"about_ca_topic_score_gemma":0.00001261711,"domain_scores_codex":[0.9957964,0.0004656192,0.0008769102,0.00036338,0.001954532,0.0005430951],"domain_scores_gemma":[0.9965419,0.0009075044,0.0003499458,0.0005774705,0.001220166,0.0004030467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01084504,0.01161252,0.5195231,0.0001828117,0.000425305,0.0002998903,0.0002149278,0.00001461687,0.005446658,0.00004033394,0.4058715,0.04552331],"study_design_scores_gemma":[0.03786726,0.04293736,0.8780221,0.0002386644,0.0003228018,0.0002177848,0.0006301146,0.0003377828,0.0002967886,0.001166297,0.03778265,0.0001804352],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980459,0.006116135,0.0002131758,0.006956257,0.001049776,0.003513992,0.00001017651,0.00005599036,0.001625451],"genre_scores_gemma":[0.9858004,0.001050149,0.005753478,0.00004758097,0.001404301,0.0001078944,0.00001364908,0.00006636334,0.00575622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3680888,"threshold_uncertainty_score":0.5091838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.300773801247584,"score_gpt":0.5101181704991435,"score_spread":0.2093443692515595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}