{"id":"W4381950620","doi":"10.1016/j.isci.2023.107205","title":"Methionine oxidation selectively enhances T cell reactivity against a melanoma antigen","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ontario Ministry of Research, Innovation and Science; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Academia Româna; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Corporation for National and Community Service","keywords":"Antigenicity; Methionine sulfoxide; Chemistry; Methionine; Peptide; Immunosurveillance; Antigen; Biochemistry; Melanoma; Amino acid; Cell; Biology; Cancer research; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054426,0.0001877944,0.0001312369,0.00008318395,0.00007084955,0.000113935,0.00007623853,0.000157667,0.001084935],"category_scores_gemma":[0.000137774,0.00006577477,0.00012673,0.00005972277,0.0001067052,0.00007502802,0.000124181,0.0002204957,0.0001541824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008037737,"about_ca_system_score_gemma":0.00007089936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002272931,"about_ca_topic_score_gemma":0.0003130032,"domain_scores_codex":[0.999916,0.00002216713,0.000006187808,0.00001458316,0.00001814102,0.00002298458],"domain_scores_gemma":[0.9999226,0.00002252327,0.0000176341,0.00000900119,0.00001073517,0.00001745303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001235499,0.000008126286,0.0001311003,0.00001277608,0.00000271255,0.00002351594,0.000006041592,0.0000143466,0.9993298,0.00001039548,0.000005321811,0.000332336],"study_design_scores_gemma":[0.000008877607,0.0007119993,0.003585614,0.000002900191,0.00001151807,0.0001521457,0.00001325295,0.0002203275,0.9947653,0.00002031184,0.0005057001,0.000002089784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991574,0.0002843187,0.0001987816,0.00001217466,0.000005944298,0.000003720634,0.00001885304,0.000005833952,0.0003130612],"genre_scores_gemma":[0.9990432,0.0001461759,0.0003301654,0.00001292479,0.000003878786,0.000002596111,0.00004314524,0.000003325624,0.0004144031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001084935,"threshold_uncertainty_score":0.003629446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662883071890007,"score_gpt":0.2651806488753161,"score_spread":0.2485518181564161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}