{"id":"W4381953497","doi":"10.1016/s0140-6736(23)01127-3","title":"Efficacy and safety of once-daily oral semaglutide 25 mg and 50 mg compared with 14 mg in adults with type 2 diabetes (PIONEER PLUS): a multicentre, randomised, phase 3b trial","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"LMC Diabetes & Endocrinology (Canada)","funders":"Steno Diabetes Center Copenhagen","keywords":"Semaglutide; Medicine; Type 2 diabetes; Internal medicine; Diabetes mellitus; Physical therapy; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001854371,0.001904756,0.004171213,0.0003304302,0.0004119033,0.001431913,0.001174116,0.002483235,0.007646753],"category_scores_gemma":[0.001756535,0.0009180725,0.003150292,0.0003904942,0.00143677,0.001404711,0.0005119933,0.003888674,0.001234246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000919803,"about_ca_system_score_gemma":0.0009106897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001838034,"about_ca_topic_score_gemma":0.00312256,"domain_scores_codex":[0.9993451,0.0003178857,0.00003643338,0.0001526734,0.00004968075,0.00009812129],"domain_scores_gemma":[0.9990042,0.0003169292,0.0002331484,0.00008450668,0.00004744537,0.0003138148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9915853,0.001189991,0.0003621354,0.0003024546,0.0008264462,0.00001830493,0.00002581064,0.0001206517,0.000835752,0.00004482473,0.0004901681,0.004198205],"study_design_scores_gemma":[0.9743999,0.02236774,0.001976637,0.00002487544,0.000599833,0.00002031481,0.00001684199,0.0001793704,0.0001083124,0.00008905112,0.0002032032,0.00001400794],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868469,0.007347486,0.0003055877,0.0007903033,0.000650662,0.0008478272,0.001115333,0.0001332043,0.001962782],"genre_scores_gemma":[0.9881511,0.00304865,0.000972761,0.001473792,0.0006091158,0.0009418949,0.001310978,0.00003658073,0.003455259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007646753,"threshold_uncertainty_score":0.02558088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02309397562777679,"score_gpt":0.2799489399427412,"score_spread":0.2568549643149645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}