{"id":"W4381953497","doi":"10.1016/s0140-6736(23)01127-3","title":"Efficacy and safety of once-daily oral semaglutide 25 mg and 50 mg compared with 14 mg in adults with type 2 diabetes (PIONEER PLUS): a multicentre, randomised, phase 3b trial","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"LMC Diabetes & Endocrinology (Canada)","funders":"Steno Diabetes Center Copenhagen","keywords":"Semaglutide; Medicine; Type 2 diabetes; Internal medicine; Diabetes mellitus; Physical therapy; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003583149,0.0001907482,0.0007807733,0.00008969857,0.00004906754,0.00002006892,0.00008691587,0.00003481859,0.00002182274],"category_scores_gemma":[0.00007667667,0.0001038703,0.00002778161,0.0003082254,0.0001496324,0.0000499271,0.00005987224,0.0001133129,0.000009294515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003220388,"about_ca_system_score_gemma":0.00003523752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000054887,"about_ca_topic_score_gemma":0.00017946,"domain_scores_codex":[0.9988659,0.00008475799,0.0002425322,0.0002423608,0.0002204567,0.000344014],"domain_scores_gemma":[0.9992002,0.0002532541,0.0001064028,0.0003120247,0.00004408577,0.00008409394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9544331,0.000736568,0.0244341,0.00050128,0.000712697,0.00006036927,0.003040114,0.0001394796,0.0004659243,0.00008451864,0.004627196,0.01076459],"study_design_scores_gemma":[0.9284661,0.002165391,0.05847247,0.0008665341,0.0005700567,0.000001459113,0.0004222121,0.005473352,0.0001554086,0.00001491561,0.003220407,0.0001717343],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950408,0.0004320687,0.000004599786,0.001098512,0.00006169919,0.002383435,0.00002297146,0.00007113412,0.0008847589],"genre_scores_gemma":[0.9982222,0.0003871332,0.0003856012,0.0001683217,0.0001307188,0.00007063794,0.00009843453,0.00002198045,0.0005149745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03403838,"threshold_uncertainty_score":0.4235709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02309397562777679,"score_gpt":0.2799489399427412,"score_spread":0.2568549643149645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}