{"id":"W4381987710","doi":"10.1002/adfm.202305771","title":"A Selective, Hydrogel‐Based Prodrug Delivery System Efficiently Activates a Suicide Gene to Remove Undifferentiated Human Stem Cells Within Neural Grafts","year":2023,"lang":"en","type":"article","venue":"Advanced Functional Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Neural stem cell; Suicide gene; Induced pluripotent stem cell; Progenitor cell; Gene delivery; Prodrug; Regenerative medicine; Stem cell; Materials science; Ganciclovir; Biomedical engineering; Cancer research; Cell biology; Genetic enhancement; Biology; Pharmacology; Medicine; Embryonic stem cell; Immunology; Biochemistry; Human cytomegalovirus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009046421,0.0003583405,0.0001180536,0.0001449218,0.00007578542,0.0001434534,0.0001762942,0.000212238,0.0005801155],"category_scores_gemma":[0.00007607084,0.00009909053,0.0001286911,0.00007380337,0.0001381206,0.0001355718,0.0001174284,0.0002099848,0.0002445222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000246916,"about_ca_system_score_gemma":0.0001969526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003343117,"about_ca_topic_score_gemma":0.0005413644,"domain_scores_codex":[0.9999304,0.000007444564,0.000005188017,0.00002253071,0.00002048645,0.00001387623],"domain_scores_gemma":[0.9999553,0.000008142422,0.00002005426,0.000004786682,0.000004480778,0.000007259667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009244722,0.000005387649,0.00001539168,0.00001216643,0.000001003004,0.00001556681,0.000003176995,0.00004041893,0.9992999,0.00004639275,0.00001111572,0.0005402436],"study_design_scores_gemma":[0.000003290706,0.00005659907,0.00014526,0.000001228423,0.000002310199,0.00004850691,0.000001614533,0.0003441466,0.9989613,0.000006516175,0.0004280742,0.000001135328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784671,0.001426376,0.01763894,0.00007004982,0.00003990101,0.0000734328,0.0002358723,0.000184518,0.001863661],"genre_scores_gemma":[0.9875789,0.0005155136,0.009358572,0.00002911795,0.000006927242,0.00004201699,0.0001493373,0.00002101586,0.002298568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005801155,"threshold_uncertainty_score":0.001940608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762899076030153,"score_gpt":0.2438702265293574,"score_spread":0.2262412357690559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}