{"id":"W4381987710","doi":"10.1002/adfm.202305771","title":"A Selective, Hydrogel‐Based Prodrug Delivery System Efficiently Activates a Suicide Gene to Remove Undifferentiated Human Stem Cells Within Neural Grafts","year":2023,"lang":"en","type":"article","venue":"Advanced Functional Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Neural stem cell; Suicide gene; Induced pluripotent stem cell; Progenitor cell; Gene delivery; Prodrug; Regenerative medicine; Stem cell; Materials science; Ganciclovir; Biomedical engineering; Cancer research; Cell biology; Genetic enhancement; Biology; Pharmacology; Medicine; Embryonic stem cell; Immunology; Biochemistry; Human cytomegalovirus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002224045,0.000347273,0.0003389569,0.0001924105,0.0002425549,0.00007799651,0.0002294474,0.0001575526,0.00003238511],"category_scores_gemma":[0.00002839148,0.0003253425,0.0001147534,0.0003676773,0.00003881203,0.0000180077,0.0001453324,0.00008608375,0.0001986377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008519164,"about_ca_system_score_gemma":0.00008390316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005736821,"about_ca_topic_score_gemma":0.00002534092,"domain_scores_codex":[0.9978799,0.0001230017,0.0004762732,0.0007604192,0.000288068,0.0004723457],"domain_scores_gemma":[0.9989594,0.00003924374,0.0002060105,0.0003875478,0.0002645543,0.0001432752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009534119,0.00006171347,0.0001505519,0.00007332912,0.00009776496,0.00001373452,0.00003526088,0.01986554,0.9777596,0.00003808452,0.0008502552,0.0001007745],"study_design_scores_gemma":[0.0007663746,0.0005395575,0.002413743,0.00009459545,0.00003168227,0.00001203401,0.0001102797,0.0003426519,0.9951586,0.00002973575,0.0001355686,0.000365233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972029,0.00004456286,0.0004248818,0.00005184286,0.001184431,0.0006377632,0.0002336072,0.0001810213,0.00003898544],"genre_scores_gemma":[0.9969294,0.000005768035,0.0001554688,0.0003764376,0.0002390116,0.0002045609,0.0008766557,0.00006142546,0.001151285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01952289,"threshold_uncertainty_score":0.9999199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762899076030153,"score_gpt":0.2438702265293574,"score_spread":0.2262412357690559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}