{"id":"W4382010997","doi":"10.1021/acs.orglett.3c01536","title":"Synthetic Analogs of the Sponge Sesterterpenoid Alotaketal C are Potent Inhibitors of SARS-CoV-2 Omicron BA.1 and BA.5 Infections of Human Lung Cells","year":2023,"lang":"en","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Pharmacophore; Chemistry; Sponge; Stereochemistry; Natural product; Human lung; Combinatorial chemistry; Cell culture; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008877556,0.0003185014,0.0002270923,0.0002317156,0.00009614421,0.0001770454,0.0001770665,0.0001778107,0.002314542],"category_scores_gemma":[0.0001322995,0.0001031234,0.0001765215,0.0001903327,0.0002215896,0.0001339355,0.0001533281,0.0004004488,0.0004128255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001647635,"about_ca_system_score_gemma":0.0002424075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004697716,"about_ca_topic_score_gemma":0.001264368,"domain_scores_codex":[0.9999281,0.0000163397,0.000007452333,0.000009348567,0.00001777193,0.00002090054],"domain_scores_gemma":[0.9999043,0.00001552025,0.00002730107,0.0000095392,0.000007531813,0.00003587547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007242739,0.0001114161,0.0002810915,0.0001436632,0.00001891582,0.000292005,0.00002960488,0.001039295,0.9897127,0.0003131129,0.0001724719,0.007161428],"study_design_scores_gemma":[0.0003514465,0.006378114,0.004270721,0.0000216777,0.00004610754,0.001294844,0.0000750895,0.001075293,0.9746661,0.0001842686,0.01160738,0.00002885892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859416,0.004405229,0.002581189,0.000143692,0.00007143583,0.0001270289,0.0008561752,0.00008321904,0.00579044],"genre_scores_gemma":[0.9942576,0.002090811,0.001690151,0.00006520536,0.00001577064,0.00003438048,0.0006360235,0.00000631128,0.001203679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002314542,"threshold_uncertainty_score":0.007742882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274813602728301,"score_gpt":0.2327749989072455,"score_spread":0.2200268628799625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}