{"id":"W4382020994","doi":"10.1038/s41571-023-00785-8","title":"Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy","year":2023,"lang":"en","type":"review","venue":"Nature Reviews Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Horizon 2020 Framework Programme; Institut Universitaire de France; Stand Up To Cancer; Genentech; Labex Immuno-Oncology; National Institutes of Health; PharmaMar; University of Texas MD Anderson Cancer Center; Ligue Contre le Cancer; AstraZeneca; Institut National Du Cancer; Fonds de Recherche du Québec - Santé; Institut National de la Santé et de la Recherche Médicale; Exelixis; Sanofi; European Commission; Daiichi Sankyo Europe; National Cancer Institute; HORIZON EUROPE Framework Programme; Gilead Sciences; Melanoma Research Alliance; GlaxoSmithKline; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; Bristol-Myers Squibb; American Association for Cancer Research; Seerave Foundation","keywords":"Dysbiosis; Medicine; Gut flora; Clinical trial; Cancer; Biomarker; Metagenomics; Bioinformatics; Oncology; Computational biology; Immunology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001176114,0.0008251659,0.001566819,0.001488988,0.0001424765,0.001339721,0.000767118,0.001186676,0.003261769],"category_scores_gemma":[0.001617923,0.0002529156,0.0006258058,0.00110629,0.0004471066,0.001314043,0.0009617354,0.002213588,0.001703711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005272009,"about_ca_system_score_gemma":0.0008601918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005293536,"about_ca_topic_score_gemma":0.001355148,"domain_scores_codex":[0.9997079,0.00006764747,0.00002412882,0.00004945873,0.0001107233,0.00004022363],"domain_scores_gemma":[0.9993901,0.0003400478,0.00007975768,0.00001526892,0.0001316966,0.00004315326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001435229,0.0000539927,0.0003824767,0.006537118,0.0001185764,0.0001405184,0.00002463517,0.000379012,0.002651363,0.003965214,0.02424276,0.9613609],"study_design_scores_gemma":[0.00009457306,0.0003261606,0.001467245,0.004421177,0.0003446156,0.0009503004,0.00006481823,0.000449679,0.002273481,0.00465765,0.984909,0.00004126523],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002476169,0.9974247,0.0003792127,0.0006483044,0.0003271431,0.00001076424,0.00006340221,0.00001720768,0.0008815788],"genre_scores_gemma":[0.002715797,0.9942477,0.0006921367,0.000972902,0.000311912,0.00002312086,0.0001540733,0.000003938251,0.0008784008],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003261769,"threshold_uncertainty_score":0.0109117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3343139125727195,"score_gpt":0.5517493436111188,"score_spread":0.2174354310383994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}