{"id":"W4382023166","doi":"10.3390/jof9070695","title":"CRISPR-Cas9 Gene Editing and Secondary Metabolite Screening Confirm Fusarium graminearum C16 Biosynthetic Gene Cluster Products as Decalin-Containing Diterpenoid Pyrones","year":2023,"lang":"en","type":"article","venue":"Journal of Fungi","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Agriculture and Agri-Food Canada","funders":"","keywords":"Gene cluster; Decalin; Biology; Terpenoid; Fusarium; Gene; CRISPR; Metabolite; Genetics; Botany; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001685934,0.000354081,0.0008546777,0.0005414975,0.0002297666,0.0001491114,0.000194764,0.0001825198,0.00009717161],"category_scores_gemma":[0.001033443,0.0002560355,0.0002220115,0.0005417248,0.0001320135,0.000352485,0.0001757829,0.0007339874,0.00003405967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004458811,"about_ca_system_score_gemma":0.0001784349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003970846,"about_ca_topic_score_gemma":0.000001962849,"domain_scores_codex":[0.9973444,0.0001298321,0.0009541093,0.0004594305,0.0005027642,0.0006094344],"domain_scores_gemma":[0.9978889,0.0002320684,0.0006168289,0.0003180313,0.0006192656,0.0003249097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006513438,0.00005790788,0.0005594713,0.0002171058,0.0003316736,0.0004981328,0.0004171515,0.000005838339,0.9249901,0.00002783738,0.001804255,0.0704392],"study_design_scores_gemma":[0.001784513,0.0006244284,0.006447516,0.0002642474,0.0006077177,0.00398654,0.0004947577,0.0002776065,0.9342789,0.00005873174,0.05084393,0.0003311025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9639671,0.01761712,0.0001263152,0.01571773,0.001690444,0.0004543714,0.00008845397,0.00008190385,0.0002565491],"genre_scores_gemma":[0.9840872,0.001350591,0.00734092,0.001389736,0.004806817,0.000001011257,0.00005905474,0.00006284061,0.0009018396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0701081,"threshold_uncertainty_score":0.9999892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902876399056518,"score_gpt":0.2654868532756878,"score_spread":0.2464580892851226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}