{"id":"W4382023166","doi":"10.3390/jof9070695","title":"CRISPR-Cas9 Gene Editing and Secondary Metabolite Screening Confirm Fusarium graminearum C16 Biosynthetic Gene Cluster Products as Decalin-Containing Diterpenoid Pyrones","year":2023,"lang":"en","type":"article","venue":"Journal of Fungi","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Agriculture and Agri-Food Canada","funders":"","keywords":"Gene cluster; Decalin; Biology; Terpenoid; Fusarium; Gene; CRISPR; Metabolite; Genetics; Botany; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002426704,0.0004583756,0.0003136514,0.0002243565,0.0002115569,0.0003304446,0.0002445812,0.0003258783,0.001393515],"category_scores_gemma":[0.000287526,0.0001111379,0.0002685584,0.0002279135,0.0002050681,0.0001837544,0.000285297,0.0004664933,0.0004200367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552592,"about_ca_system_score_gemma":0.0002359029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222565,"about_ca_topic_score_gemma":0.001855041,"domain_scores_codex":[0.999731,0.00002386132,0.00003134604,0.00008047202,0.00009512616,0.00003821176],"domain_scores_gemma":[0.9997701,0.00004831101,0.0000704079,0.00003451444,0.00003457472,0.00004207826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003915394,0.000008940467,0.0001169563,0.00001536413,0.000002219168,0.00005205529,0.00001144755,0.00005176741,0.9988868,0.00003915555,0.00001858225,0.000757559],"study_design_scores_gemma":[0.000003826543,0.00006947378,0.001750653,0.000002495444,0.000006975484,0.0001581544,0.00001738483,0.0006375124,0.995751,0.00002764296,0.001569608,0.000005253158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717106,0.0005195552,0.02065555,0.0001736757,0.00005349555,0.0001450308,0.002884412,0.0004759227,0.003381692],"genre_scores_gemma":[0.9679425,0.0005013269,0.0231752,0.00009199477,0.000006600204,0.00007529389,0.002854066,0.0001198591,0.005233139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001393515,"threshold_uncertainty_score":0.004661798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902876399056518,"score_gpt":0.2654868532756878,"score_spread":0.2464580892851226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}