{"id":"W4382025359","doi":"10.1093/bjd/ljad113.105","title":"P77 Deucravacitinib, an oral selective allosteric tyrosine kinase 2 inhibitor, vs. placebo and apremilast in moderate-to-severe plaque psoriasis: achievement of absolute Psoriasis Area and Severity Index thresholds in two phase III trials","year":2023,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; SKiN Health; Queen's University","funders":"European League Against Rheumatism; Bristol-Myers Squibb","keywords":"Medicine; Psoriasis; Psoriasis Area and Severity Index; Placebo; Apremilast; Internal medicine; Plaque psoriasis; Randomized controlled trial; Gastroenterology; Dermatology; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001901786,0.001562362,0.002664095,0.0004369006,0.0004489965,0.001434066,0.0009001722,0.001902744,0.008486796],"category_scores_gemma":[0.001407672,0.0005135973,0.003149877,0.000429584,0.0007221204,0.001034873,0.0003276764,0.003169902,0.001773956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008601029,"about_ca_system_score_gemma":0.001207113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006973685,"about_ca_topic_score_gemma":0.001662168,"domain_scores_codex":[0.999281,0.0003066364,0.00006548114,0.0001223176,0.0001010971,0.0001234682],"domain_scores_gemma":[0.9994252,0.0001840378,0.000115889,0.00004434702,0.00005073362,0.0001797583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8708752,0.009922769,0.0006346143,0.003678974,0.003115196,0.0001640943,0.0001108571,0.0008829152,0.01231695,0.0005647004,0.006407608,0.09132607],"study_design_scores_gemma":[0.9130055,0.07810852,0.00193801,0.0001464204,0.000904623,0.0001438739,0.00002758448,0.00049398,0.001337941,0.0003496314,0.003520057,0.00002370948],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.886315,0.06080749,0.003078673,0.003962309,0.00188672,0.01155106,0.005948212,0.0006568339,0.0257937],"genre_scores_gemma":[0.9580907,0.01416395,0.002484165,0.003027275,0.0006826049,0.008296705,0.00416855,0.00005803735,0.009028045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008486796,"threshold_uncertainty_score":0.02839118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0295273914414819,"score_gpt":0.2968308233280075,"score_spread":0.2673034318865256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}