{"id":"W4382045588","doi":"10.1186/s13059-023-02926-9","title":"Human papillomavirus integration transforms chromatin to drive oncogenesis","year":2023,"lang":"en","type":"article","venue":"Genome biology","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Vector Institute; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Peterborough K. M. Hunter Charitable Foundation; University of Toronto; Canadian Cancer Society; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"CTCF; Chromatin; Biology; Carcinogenesis; Genetics; Gene; Genome; Transcription factor; Computational biology; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438485,0.0001516583,0.0001150629,0.0002129182,0.000131971,0.0003958721,0.0001560807,0.0001779264,0.00232227],"category_scores_gemma":[0.0001910068,0.0001292856,0.0002127713,0.0001919131,0.0001959467,0.0001517298,0.0003316895,0.0003801075,0.0003273305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003343586,"about_ca_system_score_gemma":0.0001510633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000731875,"about_ca_topic_score_gemma":0.0009728238,"domain_scores_codex":[0.9998931,0.00001256492,0.000006325209,0.00003318955,0.0000301214,0.00002463168],"domain_scores_gemma":[0.999866,0.00004134587,0.00002690892,0.00002602715,0.00001455772,0.00002510908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002393645,0.00001859292,0.0008483862,0.00002817105,0.00000652773,0.0000309841,0.00001501085,0.00008302514,0.9969862,0.0002660136,0.00005376428,0.00163948],"study_design_scores_gemma":[0.00001160751,0.0001677945,0.01921315,0.00001076041,0.00002176208,0.0002748209,0.00004832182,0.002377193,0.9710119,0.0004799104,0.006376048,0.000006836832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811655,0.001827139,0.01309082,0.00009960425,0.00008136738,0.0000394182,0.0005863084,0.0002641256,0.00284577],"genre_scores_gemma":[0.9961544,0.0003379511,0.001871368,0.00004012042,0.000006283118,0.00001164548,0.0004079278,0.00002876548,0.001141518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00232227,"threshold_uncertainty_score":0.00776875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05927382802528405,"score_gpt":0.3958437556321496,"score_spread":0.3365699276068656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}