{"id":"W4382048299","doi":"10.1158/2159-8290.c.6714001","title":"Data from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Cancer Research UK Cambridge Institute, University of Cambridge; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Great Ormond Street Hospital Charity; National Institutes of Health; Cancer Research UK; Brain Research UK; Government of Canada; Strong; Government of Ontario; Compute Canada; Canadian Institutes of Health Research; Genome Canada","keywords":"PDGFRA; Cancer research; Histone H3; Glioma; Biology; Mutation; Molecular biology; Histone; Gene; Genetics; Stromal cell; GiST","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00102721,0.001071658,0.0007592874,0.001817399,0.0005672303,0.0007767558,0.0007047927,0.0006093712,0.004346967],"category_scores_gemma":[0.0006697212,0.0002696041,0.0008821095,0.001105421,0.0002630898,0.0004914168,0.0004904413,0.001635498,0.002604546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005445339,"about_ca_system_score_gemma":0.000819909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001672835,"about_ca_topic_score_gemma":0.003302776,"domain_scores_codex":[0.9993514,0.00006125071,0.00009741497,0.00009947652,0.0002834974,0.0001068413],"domain_scores_gemma":[0.9991429,0.0001505764,0.0001125763,0.0001789982,0.0002447082,0.0001701443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009040382,0.0003803124,0.003487476,0.0006902858,0.0002570527,0.0003827068,0.0001332926,0.001062739,0.9503456,0.0008926099,0.01001274,0.03145107],"study_design_scores_gemma":[0.0001932846,0.003409697,0.02325648,0.0002100166,0.001073157,0.003838591,0.0002652966,0.002415926,0.792298,0.0006777662,0.1722664,0.0000955034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.6886072,0.02237634,0.05813368,0.001468782,0.0005930618,0.001469053,0.1887073,0.002467342,0.03617734],"genre_scores_gemma":[0.538177,0.02936456,0.02730422,0.001362042,0.00009394113,0.002616744,0.3739191,0.001043371,0.02611907],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.004346967,"threshold_uncertainty_score":0.01454204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1514514106818641,"score_gpt":0.315542302262615,"score_spread":0.1640908915807509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}