{"id":"W4382048782","doi":"10.1080/14728222.2023.2230364","title":"SCN1A as a therapeutic target for Dravet syndrome","year":2023,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Targets","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"","keywords":"Dravet syndrome; Medicine; Epilepsy; Pediatrics; Encephalopathy; Epilepsy syndromes; Sodium channel blocker; Disease; Bioinformatics; Sodium channel; Psychiatry; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003918701,0.0005776652,0.0009190693,0.00104776,0.0001451663,0.0006713655,0.000654666,0.0009940251,0.007102801],"category_scores_gemma":[0.0006481357,0.0001317304,0.0006711787,0.0007455674,0.000232672,0.0006695467,0.0004294603,0.00160422,0.002109581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004416546,"about_ca_system_score_gemma":0.000741004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009387169,"about_ca_topic_score_gemma":0.001910022,"domain_scores_codex":[0.9998524,0.0000298719,0.00001904804,0.00002778216,0.00005411687,0.00001673967],"domain_scores_gemma":[0.9998025,0.00009498792,0.00003299936,0.000004486417,0.00005047287,0.00001458429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001135224,0.00004816293,0.00008559695,0.02505071,0.0001379191,0.0001526709,0.00004288855,0.0003676507,0.001629615,0.00381379,0.04117909,0.9273784],"study_design_scores_gemma":[0.00006865489,0.0001661273,0.0005411312,0.009756943,0.0002603661,0.0009756548,0.00004503777,0.0001639487,0.0004845516,0.002513651,0.9850073,0.00001653261],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001381192,0.9974157,0.0001136387,0.0005063077,0.0003903163,0.000009073428,0.00003643132,0.000008500464,0.001381884],"genre_scores_gemma":[0.001152751,0.9970414,0.0001895223,0.0004888828,0.000197334,0.00001156987,0.00006201512,0.000002289599,0.0008542968],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007102801,"threshold_uncertainty_score":0.02376121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.157949531177384,"score_gpt":0.4518599862497142,"score_spread":0.2939104550723303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}