{"id":"W4382049662","doi":"10.1093/genetics/iyad117","title":"Species-specific protein–protein interactions govern the humanization of the 20S proteasome in yeast","year":2023,"lang":"en","type":"article","venue":"Genetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Faculty of Arts and Sciences; National Institutes of Health; Canada Foundation for Innovation; Concordia University; National Institute of General Medical Sciences; Chesapeake Research Consortium; School of Graduate Studies, Utah State University","keywords":"Complementation; Yeast; Biology; Protein subunit; Proteasome; Protein-fragment complementation assay; Saccharomyces cerevisiae; Genetics; Gene; Two-hybrid screening; Mutant; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000220713,0.0001258372,0.00009656778,0.00004040204,0.0001200388,0.00002701831,0.0003827657,0.00008382428,0.00006789548],"category_scores_gemma":[0.00007779865,0.00008691447,0.00007941775,0.0004091144,0.0001175738,0.000003194482,0.0002438568,0.0001556123,0.00005326402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002268174,"about_ca_system_score_gemma":0.00006540071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001155055,"about_ca_topic_score_gemma":0.0001624817,"domain_scores_codex":[0.9989832,0.0001240992,0.0002434446,0.0002287723,0.0002044966,0.0002159993],"domain_scores_gemma":[0.9992114,0.000007048838,0.0001275681,0.0005458499,0.0000794049,0.00002868249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001850766,0.00003616279,0.00151609,0.00002154472,0.00001178075,7.22253e-7,0.000177544,0.0001757709,0.9948322,0.0007100818,0.001373496,0.001126132],"study_design_scores_gemma":[0.0002305062,0.00007109893,0.02264276,0.00004849134,0.000004086757,0.000003521065,0.0001782393,0.00007325947,0.8351844,0.0004622722,0.1409836,0.0001177429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950366,0.0002627938,0.0002603024,0.0005613646,0.0001522359,0.001233208,0.00006335507,0.00001613045,0.002414036],"genre_scores_gemma":[0.9930907,0.00007415838,0.0001482646,0.00005120406,0.0002577962,0.0001826068,0.00004562316,0.00002652002,0.006123102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1596478,"threshold_uncertainty_score":0.3544269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02437623590510841,"score_gpt":0.240904965075646,"score_spread":0.2165287291705376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}