{"id":"W4382049662","doi":"10.1093/genetics/iyad117","title":"Species-specific protein–protein interactions govern the humanization of the 20S proteasome in yeast","year":2023,"lang":"en","type":"article","venue":"Genetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Faculty of Arts and Sciences; National Institutes of Health; Canada Foundation for Innovation; Concordia University; National Institute of General Medical Sciences; Chesapeake Research Consortium; School of Graduate Studies, Utah State University","keywords":"Complementation; Yeast; Biology; Protein subunit; Proteasome; Protein-fragment complementation assay; Saccharomyces cerevisiae; Genetics; Gene; Two-hybrid screening; Mutant; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003081282,0.0003257158,0.0002711448,0.0001985712,0.0001968638,0.0007578073,0.0002462458,0.0002514633,0.0007520589],"category_scores_gemma":[0.0002231996,0.0002899302,0.0003518645,0.0002243295,0.0002315623,0.0003004158,0.0005040474,0.0003997611,0.0007584528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003514155,"about_ca_system_score_gemma":0.0002826969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006359466,"about_ca_topic_score_gemma":0.001121512,"domain_scores_codex":[0.999774,0.00002723875,0.000024601,0.00007784271,0.00005640389,0.00003994017],"domain_scores_gemma":[0.9998746,0.00001815105,0.00004068662,0.00002391428,0.00001485809,0.00002778591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000595885,0.00001147045,0.0003975514,0.00002718961,0.000006915384,0.00008708228,0.00002703986,0.0001290813,0.9970058,0.0002972441,0.00008478892,0.001866305],"study_design_scores_gemma":[0.00001119947,0.000107205,0.005629065,0.00001012706,0.00002401947,0.000667883,0.0000643242,0.001174451,0.9772865,0.0003108358,0.01470167,0.00001281594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781408,0.004489176,0.01336134,0.0001217192,0.00005123915,0.00004492383,0.0008058436,0.0003890268,0.002595886],"genre_scores_gemma":[0.9873226,0.002002478,0.007066871,0.0001003914,0.00001315408,0.00002590688,0.001492095,0.0001310135,0.001845435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007578073,"threshold_uncertainty_score":0.002549708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02437623590510841,"score_gpt":0.240904965075646,"score_spread":0.2165287291705376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}