{"id":"W4382051182","doi":"10.1200/po.23.00076","title":"Genomics of <i>ERBB2</i>-Positive Breast Cancer in Young Women Before and After Exposure to Chemotherapy Plus Trastuzumab","year":2023,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Trastuzumab; Breast cancer; Oncology; Copy number analysis; Exome sequencing; Internal medicine; Cancer; Biology; Copy-number variation; Chemotherapy; Medicine; Mutation; Cancer research; Gene; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002330282,0.0001541438,0.0003003137,0.0001225945,0.00002851538,0.00001244549,0.0001236492,0.0002267636,0.00005549368],"category_scores_gemma":[0.00003644716,0.0001511559,0.00004805411,0.0001944652,0.00006714911,0.000003977535,0.0002053406,0.00008898135,0.000006987032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000320614,"about_ca_system_score_gemma":0.0002952602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001323206,"about_ca_topic_score_gemma":0.00328896,"domain_scores_codex":[0.9988669,0.00004371687,0.0002964495,0.0003852096,0.00009223057,0.0003155216],"domain_scores_gemma":[0.9994291,0.00005208241,0.00008237128,0.0002291739,0.00008439452,0.0001228933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00832431,0.0003340808,0.0968186,0.00006623043,0.0001924982,0.00008173841,0.01544174,0.003470486,0.4438688,0.00005464733,0.004504982,0.4268419],"study_design_scores_gemma":[0.003751733,0.003043815,0.9496797,0.00005973104,0.00001883677,0.00007620338,0.0009314477,0.0002096545,0.01819463,0.0003508264,0.02331881,0.0003646553],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997492,0.0003016018,0.0001157629,0.0007397257,0.0002734175,0.0003635744,0.0004741718,0.000007613051,0.0002320981],"genre_scores_gemma":[0.9962921,0.001979046,0.0002745193,0.0006857403,0.0002010594,0.0002252794,0.00003648007,0.00003045614,0.0002753595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.852861,"threshold_uncertainty_score":0.616396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004726130540452299,"score_gpt":0.2662725685712719,"score_spread":0.2615464380308196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}