{"id":"W4382051182","doi":"10.1200/po.23.00076","title":"Genomics of <i>ERBB2</i>-Positive Breast Cancer in Young Women Before and After Exposure to Chemotherapy Plus Trastuzumab","year":2023,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Trastuzumab; Breast cancer; Oncology; Copy number analysis; Exome sequencing; Internal medicine; Cancer; Biology; Copy-number variation; Chemotherapy; Medicine; Mutation; Cancer research; Gene; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008704784,0.0001088342,0.000225728,0.0002946929,0.0001872017,0.0002488386,0.00007953963,0.0002191109,0.0007246759],"category_scores_gemma":[0.0004949355,0.0000732334,0.0001757804,0.0003681247,0.00009038548,0.00008044715,0.0001488206,0.0001265711,0.0001593638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001873249,"about_ca_system_score_gemma":0.0001250859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003257834,"about_ca_topic_score_gemma":0.002930735,"domain_scores_codex":[0.9999146,0.00001416165,0.00000528512,0.00003036446,0.00001223927,0.00002329746],"domain_scores_gemma":[0.9998461,0.00003730405,0.0000565556,0.000007450272,0.00001776908,0.00003489095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008794518,0.00004860944,0.9554681,0.00003826304,0.00006545783,0.002016787,0.000427167,0.0001531919,0.03074224,0.00005383843,0.0005518695,0.00955498],"study_design_scores_gemma":[0.000006414414,0.0001155578,0.9968842,0.00000381319,0.0000233508,0.001386878,0.0001553303,0.0001182725,0.0007025419,0.00002864784,0.00057228,0.000002723429],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992046,0.0001370646,0.00005670487,0.00002636732,0.000002593546,0.000004070225,0.0003570246,0.000003212498,0.0002084335],"genre_scores_gemma":[0.9987618,0.0001244148,0.000123093,0.00007151202,0.000006257566,0.00001028368,0.0006465562,0.00000520856,0.0002509081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003257834,"threshold_uncertainty_score":0.006477773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004726130540452299,"score_gpt":0.2662725685712719,"score_spread":0.2615464380308196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}