{"id":"W4382055551","doi":"10.1038/s41565-023-01404-4","title":"Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines","year":2023,"lang":"en","type":"article","venue":"Nature Nanotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":230,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Narodowa Agencja Wymiany Akademickiej; Division of Chemical, Bioengineering, Environmental, and Transport Systems; University of Pennsylvania; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; National Science Foundation","keywords":"Adjuvant; Immunogenicity; Immune system; Innate immune system; Immunity; Messenger RNA; Lipid A; Acquired immune system; Immunology; Virology; Medicine; Biology; Lipopolysaccharide; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002374778,0.0002139669,0.0002618522,0.0001406866,0.0001180372,0.00001246556,0.0007227631,0.0008998199,0.000009416719],"category_scores_gemma":[0.0002400526,0.0001520929,0.0001613623,0.0005417853,0.0002002733,0.000005705509,0.0003773014,0.0004293382,0.00006637665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001609715,"about_ca_system_score_gemma":0.00007488328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003955622,"about_ca_topic_score_gemma":0.0001533326,"domain_scores_codex":[0.9986529,0.00005834095,0.0003382201,0.0004036115,0.0001633503,0.0003835134],"domain_scores_gemma":[0.998859,0.00002861241,0.0001529991,0.0007695272,0.0001683864,0.000021515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001542453,0.00004769281,0.0005586477,0.00001272973,0.0001138738,0.000005677642,0.00003077188,0.00002670803,0.9846717,0.0003144756,0.0085921,0.005471353],"study_design_scores_gemma":[0.0004764242,0.000228287,0.001312505,0.0000189445,0.00003182299,0.00002648918,0.00007856904,0.00006246947,0.9601666,0.0002623577,0.03716974,0.000165808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931466,0.003559476,0.00005390547,0.002039034,0.0007645435,0.0002303041,0.00003003785,0.00010615,0.00006997089],"genre_scores_gemma":[0.9977614,0.001189227,0.00008699972,0.0005091542,0.0001921778,0.00003941894,0.00006340914,0.00002132193,0.0001369288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02857764,"threshold_uncertainty_score":0.6940235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01461649075860012,"score_gpt":0.2771788708588739,"score_spread":0.2625623801002738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}