{"id":"W4382072007","doi":"10.1101/2023.06.23.546104","title":"Parkinson’s Disease Pathology is Directly Correlated to SIRT3 in Human Subjects and Animal Models: Implications for AAV.SIRT3-myc as a Disease-Modifying Therapy","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; The Scarborough Hospital; University of Toronto","funders":"","keywords":"SIRT3; Pars compacta; Substantia nigra; Parkinson's disease; Dopaminergic; Sirtuin; Biology; Alpha-synuclein; Hippocampus; Internal medicine; Endocrinology; Neuroscience; Disease; Dopamine; Medicine; Pathology; Acetylation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005330855,0.0003675817,0.0003804303,0.0002761197,0.0001272942,0.0003724761,0.0002473755,0.0004478688,0.001734243],"category_scores_gemma":[0.0002129089,0.0001318701,0.0003995192,0.0001987089,0.0003506921,0.0002536074,0.0001677284,0.000498852,0.0002794538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003396908,"about_ca_system_score_gemma":0.0002126066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009083088,"about_ca_topic_score_gemma":0.001732296,"domain_scores_codex":[0.9998336,0.00003723321,0.00001462427,0.00004304833,0.0000457407,0.00002569921],"domain_scores_gemma":[0.9998749,0.00001648568,0.00005229053,0.0000184292,0.00001287183,0.00002492688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009360023,0.0003275996,0.002229308,0.0001238977,0.00005738627,0.000115136,0.00003285685,0.00009287258,0.9837106,0.0003043209,0.0003063911,0.01176364],"study_design_scores_gemma":[0.0005558445,0.01579699,0.1182643,0.0001244108,0.0004997305,0.002811063,0.0001764074,0.005640106,0.8296325,0.0009184286,0.02552497,0.00005529948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739827,0.00994446,0.01091703,0.000611293,0.0001675064,0.0001852236,0.0009486166,0.0004964514,0.002746709],"genre_scores_gemma":[0.9880492,0.00291149,0.004924443,0.0001838715,0.00003618808,0.0001299177,0.000813344,0.00004158467,0.002909972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001734243,"threshold_uncertainty_score":0.005801678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04966335938273317,"score_gpt":0.3042120244892124,"score_spread":0.2545486651064792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}