{"id":"W4382117416","doi":"10.1101/2023.06.23.546123","title":"PINK1 Deficiency Alters Muscle Stem Cell Fate Decision and Muscle Regenerative Capacity","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Mitophagy; PINK1; Cell biology; Parkin; Biology; Mitochondrion; Regulator; Stem cell; Regeneration (biology); Cell fate determination; Myocyte; Autophagy; Genetics; Apoptosis; Transcription factor; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460655,0.0003299463,0.0003432848,0.0005155703,0.0001328499,0.0003679486,0.0001923192,0.0004201757,0.002685023],"category_scores_gemma":[0.0001139128,0.0001897874,0.0001958134,0.0002299831,0.0004297257,0.0002494291,0.000324849,0.0005314215,0.0005086872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002977475,"about_ca_system_score_gemma":0.000138358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005299932,"about_ca_topic_score_gemma":0.0005787367,"domain_scores_codex":[0.9998548,0.00002028633,0.00001933418,0.00004331338,0.00002813283,0.00003408514],"domain_scores_gemma":[0.9998124,0.00001939523,0.00007178941,0.00001659338,0.00001217569,0.00006771729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002158478,0.00001612361,0.0004224152,0.00002918598,0.000006879636,0.00006969488,0.00001730989,0.00006053927,0.9982382,0.000105778,0.00003260455,0.0007853776],"study_design_scores_gemma":[0.00002920968,0.0003139653,0.01747861,0.00001478158,0.0000350965,0.000602716,0.00009791461,0.001236722,0.9773541,0.0001972371,0.002629707,0.000009908604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959757,0.001027172,0.00132302,0.00006609152,0.00002207767,0.00001079122,0.0006972316,0.00009706961,0.0007809055],"genre_scores_gemma":[0.9941269,0.000516694,0.001013125,0.00004255939,0.000005665031,0.00001603809,0.0005158084,0.00003981692,0.003723454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002685023,"threshold_uncertainty_score":0.008982241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02958216113148878,"score_gpt":0.2449819687556859,"score_spread":0.2153998076241971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}