{"id":"W4382134316","doi":"10.3390/cancers15133341","title":"Radiation-Induced Cellular Senescence Reduces Susceptibility of Glioblastoma Cells to Oncolytic Vaccinia Virus","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta; Alberta Cancer Foundation; Government of Alberta","keywords":"Oncolytic virus; Senescence; Vaccinia; Radiation therapy; Cancer research; Biology; Cancer; Virus; Cancer cell; Glioma; Cell culture; Virology; Immunology; Medicine; Cell biology; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461053,0.0002511817,0.0003004384,0.0002138133,0.00008040397,0.0001955184,0.0001189066,0.0001876997,0.0008484344],"category_scores_gemma":[0.0001493956,0.0001051136,0.0002693692,0.0001273837,0.0001085518,0.0001357665,0.000145026,0.000301378,0.0002004165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001561133,"about_ca_system_score_gemma":0.0001754823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006038659,"about_ca_topic_score_gemma":0.0005198501,"domain_scores_codex":[0.9998907,0.00002954275,0.00001447941,0.00001818301,0.00002090628,0.0000262513],"domain_scores_gemma":[0.9999261,0.00001848081,0.00001992055,0.00001212253,0.0000110566,0.00001231415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009661335,0.00002851194,0.0001927507,0.00002882358,0.000006664871,0.000009743961,0.00001837841,0.00005156399,0.9983814,0.00003206224,0.00002452464,0.001128961],"study_design_scores_gemma":[0.00001405671,0.001380785,0.007959752,0.00001109654,0.00002318588,0.0001557049,0.00002672402,0.0006209904,0.9875766,0.00004003835,0.00218611,0.000005032911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949255,0.002810991,0.001262555,0.00003038283,0.00002668592,0.00002127187,0.0001599884,0.00004935925,0.0007132884],"genre_scores_gemma":[0.9955781,0.001589509,0.001082044,0.00003097793,0.000008575574,0.00002806903,0.0004362029,0.00001866152,0.001227718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008484344,"threshold_uncertainty_score":0.002838314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0191987512048617,"score_gpt":0.3091696117045196,"score_spread":0.2899708604996579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}