{"id":"W4382138110","doi":"10.3390/cells12131715","title":"Dependency of Tamoxifen Sensitive and Resistant ER+ Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Terry Fox Research Institute; U.S. Department of Defense","keywords":"Biology; Cancer research; MCF-7; Semaphorin; Autocrine signalling; Estrogen receptor; Breast cancer; Protein kinase B; Cancer; Cell culture; Signal transduction; Receptor; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196714,0.0001706119,0.0002364444,0.0001118948,0.000138378,0.00002249185,0.0001487504,0.00006537912,0.0000299023],"category_scores_gemma":[0.00006326396,0.0001539271,0.00008045323,0.0003457638,0.0001016566,0.00008607843,0.00007344014,0.0001188431,0.00005384755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002961495,"about_ca_system_score_gemma":0.00005432272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007932953,"about_ca_topic_score_gemma":0.00001766987,"domain_scores_codex":[0.9985278,0.00007645696,0.0002485545,0.0004994155,0.0002938796,0.0003539388],"domain_scores_gemma":[0.9988772,0.0006429167,0.0001329514,0.0001736383,0.00007141515,0.0001019234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002515158,0.00003223992,0.00004482193,0.0001011029,0.00000507316,0.0000518887,0.0002306032,0.00007296138,0.996278,0.0006559181,0.001803424,0.0004724585],"study_design_scores_gemma":[0.0003676412,0.0001469436,0.001264322,0.0001077312,0.00001730561,0.000005795523,0.0000779226,0.0002610064,0.9964859,0.000653279,0.0004466397,0.0001654708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972004,0.00003499291,0.00006947349,0.0003783952,0.0003610187,0.0004157221,0.0005254894,0.00006727174,0.000947201],"genre_scores_gemma":[0.9976398,0.0004082612,0.00004010388,0.0005352761,0.000119528,0.00003012231,0.000001900523,0.00003248802,0.001192497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356784,"threshold_uncertainty_score":0.6276963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03359858110840034,"score_gpt":0.2740430455847449,"score_spread":0.2404444644763446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}