{"id":"W4382138110","doi":"10.3390/cells12131715","title":"Dependency of Tamoxifen Sensitive and Resistant ER+ Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Terry Fox Research Institute; U.S. Department of Defense","keywords":"Biology; Cancer research; MCF-7; Semaphorin; Autocrine signalling; Estrogen receptor; Breast cancer; Protein kinase B; Cancer; Cell culture; Signal transduction; Receptor; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001732289,0.0001784511,0.0003027257,0.0002723046,0.0002628594,0.0003489647,0.0001741635,0.0002880484,0.003186266],"category_scores_gemma":[0.0001815204,0.0001609543,0.0004184481,0.0004092761,0.0001426986,0.0001825623,0.000174686,0.0005781234,0.001602957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002790433,"about_ca_system_score_gemma":0.0003478966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003212819,"about_ca_topic_score_gemma":0.004878805,"domain_scores_codex":[0.9996356,0.00003899106,0.00005050922,0.0000757368,0.0001311618,0.0000679611],"domain_scores_gemma":[0.9998606,0.00003511209,0.00002081305,0.00002944118,0.00002882219,0.00002508054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002380193,0.0000821943,0.001191803,0.00005872784,0.00001687833,0.00007472052,0.00003624465,0.0000653066,0.9939312,0.0001564766,0.0006371191,0.003511387],"study_design_scores_gemma":[0.0000629784,0.0008976536,0.09965748,0.00002551315,0.00006065087,0.001374962,0.0001954111,0.003123197,0.8732278,0.0001729903,0.02117443,0.00002687596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815104,0.003105404,0.001431246,0.000420988,0.00006697648,0.0000554151,0.008284732,0.0001450477,0.004979835],"genre_scores_gemma":[0.9643903,0.002723263,0.003258138,0.0005321433,0.00001846569,0.000189811,0.01736812,0.00006162215,0.01145819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003212819,"threshold_uncertainty_score":0.0106591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03359858110840034,"score_gpt":0.2740430455847449,"score_spread":0.2404444644763446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}