{"id":"W4382138646","doi":"10.1038/s41467-023-39487-1","title":"NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Monash Biomedicine Discovery Institute, Monash University; National Health and Medical Research Council; Hudson Institute of Medical Research; State Government of Victoria; University of Melbourne; Monash University; Medical Research Council; Deutscher Akademischer Austauschdienst; Public Health Agency; Public Health Agency of Canada; U.S. Department of Defense","keywords":"Inflammasome; NOD1; Cell biology; Helicobacter pylori; Immunology; Biology; Interleukin; Pyrin domain; Myeloid; Innate immune system; Inflammation; Cytokine; Immune system; NOD2; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004868078,0.0007297352,0.0004528204,0.0009505719,0.0003078936,0.0005218324,0.0004159269,0.0008845549,0.002576455],"category_scores_gemma":[0.0002396112,0.0005537727,0.0006028254,0.0002264037,0.0006479161,0.0005025604,0.0004957762,0.001773614,0.001131861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005559219,"about_ca_system_score_gemma":0.0003261875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003483516,"about_ca_topic_score_gemma":0.0005163727,"domain_scores_codex":[0.9995623,0.0000840256,0.00004525731,0.0001098383,0.00008231133,0.0001161594],"domain_scores_gemma":[0.9995164,0.00003713233,0.0001688027,0.00004938385,0.00002520582,0.0002030475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000745828,0.0001436246,0.00036307,0.00006130735,0.000007918472,0.0001764827,0.00004590368,0.00005695512,0.9969024,0.0002257025,0.00007887514,0.001191802],"study_design_scores_gemma":[0.0003832859,0.002328727,0.01791894,0.00005515331,0.00005599129,0.001973565,0.0001883027,0.001800868,0.9693011,0.0004842739,0.005489139,0.00002063808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902685,0.002334758,0.002678882,0.0006315781,0.00009431128,0.00007695495,0.0009851163,0.0002749507,0.002654917],"genre_scores_gemma":[0.9873942,0.001481501,0.00248682,0.0003096896,0.00003936432,0.0001565901,0.0009664058,0.00007916641,0.007086236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002576455,"threshold_uncertainty_score":0.00861907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01342074316398027,"score_gpt":0.3009775112581903,"score_spread":0.28755676809421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}