{"id":"W4382138807","doi":"10.1158/1078-0432.ccr-22-3915","title":"Safety, Efficacy, and Biomarker Analyses of Dostarlimab in Patients with Endometrial Cancer: Interim Results of the Phase I GARNET Study","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; BC Cancer Agency; University of British Columbia Hospital; McGill University Health Centre","funders":"Eisai; AstraZeneca","keywords":"Endometrial cancer; Microsatellite instability; Medicine; Internal medicine; Interim analysis; Biomarker; Cancer; Interim; Oncology; Clinical trial; Microsatellite; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002413589,0.0007895047,0.001161176,0.0002319149,0.0001948299,0.0005746024,0.0003615663,0.0004826836,0.001314818],"category_scores_gemma":[0.001238183,0.00024513,0.0008336016,0.000203349,0.0003284424,0.0004132448,0.0002326806,0.000900778,0.0003023824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004655609,"about_ca_system_score_gemma":0.0006606168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001934447,"about_ca_topic_score_gemma":0.0005892074,"domain_scores_codex":[0.9994066,0.0003931863,0.00002739682,0.0000482747,0.00006990348,0.00005466751],"domain_scores_gemma":[0.9991581,0.0001942899,0.0003001603,0.00009327549,0.00006649178,0.0001876703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5643908,0.01353254,0.09312759,0.001440883,0.003422726,0.0004099235,0.0003836852,0.004505882,0.06144119,0.0003122188,0.006991923,0.2500407],"study_design_scores_gemma":[0.2049634,0.5319055,0.2106113,0.0001655775,0.003884376,0.001561665,0.0001396204,0.003412564,0.02647997,0.0004615861,0.01633752,0.00007700511],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903589,0.005907034,0.0004535107,0.0002978031,0.00005254441,0.0005077178,0.0009163659,0.00007101621,0.001435093],"genre_scores_gemma":[0.9915001,0.00139838,0.001560657,0.0004945402,0.0001020882,0.0006376477,0.003141593,0.00002303103,0.001141843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002413589,"threshold_uncertainty_score":0.01276439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3938789069105098,"score_gpt":0.5904624695724283,"score_spread":0.1965835626619186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}