{"id":"W4382138807","doi":"10.1158/1078-0432.ccr-22-3915","title":"Safety, Efficacy, and Biomarker Analyses of Dostarlimab in Patients with Endometrial Cancer: Interim Results of the Phase I GARNET Study","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; BC Cancer Agency; University of British Columbia Hospital; McGill University Health Centre","funders":"Eisai; AstraZeneca","keywords":"Endometrial cancer; Microsatellite instability; Medicine; Internal medicine; Interim analysis; Biomarker; Cancer; Interim; Oncology; Clinical trial; Microsatellite; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002928651,0.0001686738,0.0008938332,0.0006589858,0.00007705974,0.00001277907,0.0002865317,0.0001034103,0.0001843008],"category_scores_gemma":[0.003842488,0.00009144069,0.0001404245,0.005134242,0.0007357614,0.00004835665,0.0004091796,0.0005323283,0.000003426845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001787871,"about_ca_system_score_gemma":0.0004319926,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007190879,"about_ca_topic_score_gemma":0.001057462,"domain_scores_codex":[0.9956403,0.0008445835,0.001212259,0.0005436912,0.001337776,0.0004213788],"domain_scores_gemma":[0.9952077,0.003248407,0.0002548218,0.0005530631,0.0005302729,0.0002057204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1333962,0.005128413,0.7663062,0.0001026148,0.0006104434,0.00001842197,0.0002095729,0.000008890624,0.0002543475,0.00000172842,0.0004623513,0.09350076],"study_design_scores_gemma":[0.1250476,0.009539286,0.8634396,0.0003496396,0.0001844986,1.759868e-7,0.0002032523,0.00002046173,0.0007451202,0.00001221164,0.0003802922,0.000077877],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955079,0.0006233668,3.461322e-7,0.0007826134,0.0002718484,0.001991362,0.000492261,0.00001395715,0.0003163763],"genre_scores_gemma":[0.9982505,0.001242098,0.00001073268,0.00003186403,0.0001001474,0.0001216744,0.00004076104,0.00002214708,0.0001800491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09713334,"threshold_uncertainty_score":0.9994203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3938789069105098,"score_gpt":0.5904624695724283,"score_spread":0.1965835626619186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}