{"id":"W4382182107","doi":"10.1097/tp.0000000000004607","title":"Regulatory T Cell Biomarkers Identify Patients at Risk of Developing Acute Cellular Rejection in the First Year Following Heart Transplantation","year":2023,"lang":"en","type":"article","venue":"Transplantation","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of Manitoba; Providence Health Care; University of Alberta; University of Saskatchewan; Mount Sinai Hospital; University of Ottawa; Prevention of Organ Failure; St. Paul's Hospital; Montreal Heart Institute; University of British Columbia; Providence Health Care Research Institute; Dalhousie University; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Biomarker; Transplantation; Heart transplantation; CD8; T cell; Regulatory T cell; Immunology; Internal medicine; Immune system; Oncology; IL-2 receptor; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006094937,0.0003277736,0.0003943538,0.0006436218,0.0001761581,0.0005028745,0.0001895337,0.0003455893,0.000904264],"category_scores_gemma":[0.001292102,0.00008501939,0.0002680302,0.0003494061,0.0001395325,0.0002133641,0.0002376718,0.0003650688,0.0002092429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001483729,"about_ca_system_score_gemma":0.0001690972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003165543,"about_ca_topic_score_gemma":0.0004981591,"domain_scores_codex":[0.9997686,0.00006214628,0.00002412325,0.00004897835,0.00004811703,0.00004815155],"domain_scores_gemma":[0.9991966,0.0002380173,0.0002684326,0.00003647545,0.0001217788,0.0001386858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005336117,0.00005807911,0.9923396,0.00001225498,0.00002893333,0.00007922613,0.00002656531,0.0001348654,0.002766446,0.000008568434,0.00006690228,0.003944808],"study_design_scores_gemma":[0.00001700647,0.0009395453,0.9946754,0.00001028514,0.00008104695,0.0005811398,0.0000884695,0.00114794,0.002156968,0.00003844404,0.0002577881,0.000005921641],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993067,0.0002108118,0.000156683,0.00001138895,0.000004850261,0.000008861639,0.00008184527,0.000006186905,0.0002126347],"genre_scores_gemma":[0.9993756,0.00005802743,0.0002562968,0.00001548295,0.00001002481,0.000009416684,0.0001850491,0.00000132109,0.00008877912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000904264,"threshold_uncertainty_score":0.0032233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009536943098308558,"score_gpt":0.2246461087771883,"score_spread":0.2151091656788798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}