{"id":"W4382182107","doi":"10.1097/tp.0000000000004607","title":"Regulatory T Cell Biomarkers Identify Patients at Risk of Developing Acute Cellular Rejection in the First Year Following Heart Transplantation","year":2023,"lang":"en","type":"article","venue":"Transplantation","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of Manitoba; Providence Health Care; University of Alberta; University of Saskatchewan; Mount Sinai Hospital; University of Ottawa; Prevention of Organ Failure; St. Paul's Hospital; Montreal Heart Institute; University of British Columbia; Providence Health Care Research Institute; Dalhousie University; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Biomarker; Transplantation; Heart transplantation; CD8; T cell; Regulatory T cell; Immunology; Internal medicine; Immune system; Oncology; IL-2 receptor; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004913731,0.0001640905,0.0002093726,0.000280579,0.0002887682,0.00000953612,0.0001689308,0.0002411788,0.00003267576],"category_scores_gemma":[0.000006156855,0.0001410173,0.00013793,0.0004699148,0.00007937497,0.0001463916,0.00001039535,0.0001912289,0.0003021801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006138879,"about_ca_system_score_gemma":0.00002689872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002433185,"about_ca_topic_score_gemma":0.0003161749,"domain_scores_codex":[0.9985914,0.0003251027,0.0004252921,0.0002778317,0.00009122828,0.0002892027],"domain_scores_gemma":[0.9994181,0.0001963811,0.0001595457,0.0001850354,0.00003232029,0.000008631866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004734123,0.00006274387,0.09693862,0.0001555671,0.0001519852,0.00001815182,0.005604279,0.00004663312,0.8960921,0.00003037971,0.0003056737,0.0001204895],"study_design_scores_gemma":[0.003130295,0.0001024714,0.3962862,0.00008565446,0.000292875,0.00001481571,0.0004475797,0.000007777659,0.5989786,0.00007383694,0.0004116425,0.0001682349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978394,0.0001529663,0.0003796547,0.0001002125,0.0008057507,0.0003728379,0.00008521374,0.00007482995,0.0001891633],"genre_scores_gemma":[0.9969239,0.001057137,0.00006790701,0.00003725884,0.000009405761,0.00003025334,0.00168212,0.00001826275,0.0001737458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2993476,"threshold_uncertainty_score":0.5750518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009536943098308558,"score_gpt":0.2246461087771883,"score_spread":0.2151091656788798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}