{"id":"W4382182886","doi":"10.1002/jev2.12337","title":"Small extracellular vesicles derived from human adipose‐derived mesenchymal stromal cells cultured in a new chemically‐defined contaminate‐free media exhibit enhanced biological and therapeutic effects on human chondrocytes in vitro and in a mouse osteoarthritis model","year":2023,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Japan Society for the Promotion of Science; Japan Agency for Medical Research and Development","keywords":"Mesenchymal stem cell; In vitro; Stromal cell; Adipose tissue; Extracellular vesicles; Microvesicles; Cell culture; Nanoparticle tracking analysis; Extracellular; Cell biology; Biology; Chemistry; Cancer research; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002725969,0.000285929,0.0001633158,0.000200776,0.0001219458,0.0003539005,0.0001152416,0.0002779761,0.0003095829],"category_scores_gemma":[0.0002152969,0.0001113235,0.0002758027,0.0001203272,0.0001860325,0.0002373153,0.0002599073,0.0002713732,0.0001605523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001615849,"about_ca_system_score_gemma":0.0002011449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002817744,"about_ca_topic_score_gemma":0.0006497177,"domain_scores_codex":[0.9998158,0.00003208514,0.00002936272,0.00003374083,0.00007047191,0.00001871499],"domain_scores_gemma":[0.9998877,0.0000250146,0.00004033059,0.00001160103,0.00001971729,0.00001574376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005312516,0.000009662474,0.000158719,0.00003468902,0.000004091517,0.00003292293,0.00001282758,0.00005013641,0.9985186,0.00005136625,0.00001012667,0.001063761],"study_design_scores_gemma":[0.000007102421,0.0001612035,0.001480804,0.000005880561,0.00001697562,0.0001695141,0.00001683923,0.0003095031,0.9963381,0.00001396016,0.001475251,0.000004879542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989986,0.002180072,0.006424773,0.00006156178,0.00003347857,0.00005495056,0.0002476344,0.00003987313,0.0009715977],"genre_scores_gemma":[0.9889578,0.001304022,0.007535581,0.00004863553,0.00001242052,0.00006564309,0.0005442528,0.0000183722,0.001513417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003539005,"threshold_uncertainty_score":0.001441658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02271382118783065,"score_gpt":0.2471002357077803,"score_spread":0.2243864145199497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}