{"id":"W4382197039","doi":"10.1016/j.celrep.2023.112714","title":"Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of British Columbia","funders":"Canadian Institutes of Health Research; Simons Foundation Autism Research Initiative; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Simons Foundation","keywords":"Glutamatergic; Neurexin; RNA splicing; Sulfation; Alternative splicing; Autism; Transmission (telecommunications); Chemistry; Neuroscience; Cell biology; Biology; Biochemistry; Computer science; Medicine; Glutamate receptor; Gene; Postsynaptic potential; Psychiatry; Messenger RNA; Telecommunications; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102835,0.0002987261,0.0001260838,0.0001098876,0.0001136762,0.0002313957,0.0001312488,0.0001522749,0.0009142656],"category_scores_gemma":[0.0000821747,0.00006888902,0.0001604647,0.00007759668,0.0002813583,0.0001717577,0.0002395804,0.0002140393,0.0002165924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003055749,"about_ca_system_score_gemma":0.0002048892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007073436,"about_ca_topic_score_gemma":0.001029866,"domain_scores_codex":[0.9999166,0.00001508229,0.000008049489,0.00001840706,0.00002678778,0.00001508158],"domain_scores_gemma":[0.9999381,0.000004683668,0.00002837892,0.00000585137,0.000007986107,0.00001492542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008317073,0.000007351837,0.001018173,0.00001938507,0.00000552545,0.0001516986,0.00002059547,0.00009337974,0.9937977,0.0008093085,0.00003363264,0.003960019],"study_design_scores_gemma":[0.00001609197,0.0002681,0.04406302,0.00001703623,0.00002489745,0.0008317562,0.0001342513,0.001814915,0.9470314,0.001080262,0.004708473,0.000009644962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916444,0.001491665,0.004150397,0.0001384293,0.00001870351,0.000007540906,0.00008016546,0.0000414334,0.00242719],"genre_scores_gemma":[0.9949669,0.001003517,0.001514679,0.00004209155,0.00000721166,0.000005133491,0.00008580258,0.000009992139,0.002364553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009142656,"threshold_uncertainty_score":0.003058553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005590888587078784,"score_gpt":0.2224819760725017,"score_spread":0.2168910874854229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}