{"id":"W4382198358","doi":"10.21203/rs.3.rs-3084565/v1","title":"Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"CDH1; Methylation; CpG site; Epigenetics; DNA methylation; Enhancer; Pathogenesis; Cancer research; Inflammatory bowel disease; GERD; Gastroenterology; Medicine; Biology; Immunology; Molecular biology; Internal medicine; Disease; Gene; Gene expression; Cadherin; Genetics; Cell; Reflux","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001209206,0.0001831939,0.0003305606,0.0005375197,0.0002323064,0.0002776122,0.00009052324,0.0002825341,0.002279939],"category_scores_gemma":[0.0006639368,0.0001178821,0.0001207763,0.000354976,0.0001574486,0.0001201498,0.000162022,0.0002216648,0.0001952985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008874712,"about_ca_system_score_gemma":0.00005508187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006414051,"about_ca_topic_score_gemma":0.000609436,"domain_scores_codex":[0.9998672,0.00003368241,0.0000161098,0.00004333619,0.00001874912,0.00002091223],"domain_scores_gemma":[0.9996161,0.00009633641,0.0001451044,0.0000237892,0.00003822231,0.00008030608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009959914,0.0000399255,0.978003,0.00004516255,0.00007195814,0.0004159894,0.0001830493,0.00004128616,0.0161687,0.00001246031,0.00009498493,0.003927433],"study_design_scores_gemma":[0.00001275094,0.0001616218,0.9973986,0.000005372026,0.00003580421,0.001095473,0.0000996747,0.0001128774,0.0009073745,0.00002142874,0.0001464523,0.000002495581],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994544,0.0002461556,0.00005485151,0.00001290043,0.000003486269,0.000001826951,0.00008565351,0.000002886624,0.0001378462],"genre_scores_gemma":[0.999728,0.00004651224,0.00004948436,0.000008892861,0.00000501319,0.000001945241,0.00006292362,0.000001084965,0.00009614022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002279939,"threshold_uncertainty_score":0.00762713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03406271612708025,"score_gpt":0.3468445727300906,"score_spread":0.3127818566030104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}